GPA33, glycoprotein A33, 10223

N. diseases: 15; N. variants: 1
Disease: Colon Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE We have developed MGD007 (anti-glycoprotein A33 x anti-CD3), a DART protein designed to redirect T cells to target gpA33 expressing colon cancer. 29866746 2018
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 GeneticVariation disease BEFREE Furthermore, 19% of all heterozygous and 37% of all homozygous gpA33(ΔN-Bcat) mice spontaneously developed aberrant crypt foci and adenomatous polyps, at frequencies and latencies akin to those observed in sporadic colon cancer in humans. 26398937 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE Glycoprotein A33 (GPA33) is a well-known colon cancer marker and a humanized antibody against it was used to target the α-sarcin. 22718791 2012
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 AlteredExpression disease BEFREE KLF4-dependent, PPARgamma-induced expression of GPA33 in colon cancer cell lines. 19551868 2009
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.050 Biomarker disease BEFREE The gpA33 antigen is a promising target for ADEPT in colon cancer, as it is expressed by >95% of human colon cancers, but is absent in all non-gastrointestinal tissues. 17786329 2007