|
Progressive supranuclear palsy
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases.
|
30089514 |
2018 |
|
Progressive supranuclear palsy
|
0.430 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to investigate the effect of genes previously identified as risk alleles, including microtubule-associated protein tau, myelin-associated oligodendrocyte basic protein, eukaryotic translation initiation factor 2-alpha kinase 3, and syntaxin 6, as well as apolipoprotein E, on cognitive function in progressive supranuclear palsy.
|
29076559 |
2017 |
|
Progressive supranuclear palsy
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
A variant in Syntaxin 6 (a soluble N-ethylmaleimide-sensitive factor attachment protein receptor STX6) (rs1411478) has been shown to be associated with progressive supranuclear palsy (PSP).
|
23415606 |
2013 |
|
Progressive supranuclear palsy
|
0.430 |
Biomarker
|
disease |
CTD_human |
We found significant previously unidentified signals (P < 5 × 10(-8)) associated with PSP risk at STX6, EIF2AK3 and MOBP.
|
21685912 |
2011 |
|
Progressive supranuclear palsy
|
0.430 |
GeneticVariation
|
disease |
GWASDB |
We found significant previously unidentified signals (P < 5 × 10(-8)) associated with PSP risk at STX6, EIF2AK3 and MOBP.
|
21685912 |
2011 |
|
Progressive supranuclear palsy
|
0.430 |
GeneticVariation
|
disease |
BEFREE |
We found significant previously unidentified signals (P < 5 × 10(-8)) associated with PSP risk at STX6, EIF2AK3 and MOBP.
|
21685912 |
2011 |
|
Progressive supranuclear palsy
|
0.430 |
GeneticVariation
|
disease |
GWASCAT |
We found significant previously unidentified signals (P < 5 × 10(-8)) associated with PSP risk at STX6, EIF2AK3 and MOBP.
|
21685912 |
2011 |
|
CEROID LIPOFUSCINOSIS, NEURONAL, 6
|
0.300 |
Biomarker
|
disease |
CTD_human |
Increased zinc and manganese in parallel with neurodegeneration, synaptic protein changes and activation of Akt/GSK3 signaling in ovine CLN6 neuronal ceroid lipofuscinosis.
|
23516525 |
2013 |
|
Ophthalmoplegia, Progressive Supranuclear
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
|
21685912 |
2011 |
|
Supranuclear Palsy, Progressive, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
|
21685912 |
2011 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Age at menopause
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
|
26414677 |
2015 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The Cancer Genome Atlas analysis showed increased syntaxin 6 expressions associated with higher Gleason score and decreased progression-free survival in PCa patients.
|
31674708 |
2020 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The Cancer Genome Atlas analysis showed increased syntaxin 6 expressions associated with higher Gleason score and decreased progression-free survival in PCa patients.
|
31674708 |
2020 |
|
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
STX6 is overexpressed in many types of human cancer.
|
22573826 |
2012 |
|
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
STX6 is overexpressed in many types of human cancer.
|
22573826 |
2012 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer.
|
31674708 |
2020 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Syntaxin 6-mediated exosome secretion regulates enzalutamide resistance in prostate cancer.
|
31674708 |
2020 |
|
Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
When stratifying the data based on histological subtype, the papillary RCC subtype exhibited a significant correlation between syntaxin 6 expression and survival.
|
30816681 |
2019 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
When stratifying the data based on histological subtype, the papillary RCC subtype exhibited a significant correlation between syntaxin 6 expression and survival.
|
30816681 |
2019 |
|
Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, our studies reveals that trafficking-related gene Stx6 may regulate intracellular calcium and is involved in the occurrence of cardiac arrhythmia, which provides new insights in that miR-1 participates in arrhythmia by regulating the trafficking-related genes and pathway.
|
28397788 |
2017 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings demonstrate that RABGEF1 mediates RE fusion with GcAVs through the STX6-VAMP3-VTI1B complex, and reveal the SNARE dynamics involved in autophagosome formation in response to bacterial infection.
|
27791468 |
2017 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, we found that Stx6 was decreased in the heart of mice after myocardial infarction and in the hypoxic cardiomyocytes, and further confirmed that Stx6 is a target of miR-1.
|
28397788 |
2017 |
|
Adverse Event Associated with Cardiac Arrhythmia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, our studies reveals that trafficking-related gene Stx6 may regulate intracellular calcium and is involved in the occurrence of cardiac arrhythmia, which provides new insights in that miR-1 participates in arrhythmia by regulating the trafficking-related genes and pathway.
|
28397788 |
2017 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Here, we have found that the expression of STX6 was up-regulated in ESCC samples, its expression was significantly correlated with tumor size, histological differentiation, lymph node metastasis and depth.
|
26906622 |
2016 |