CDKN1A, cyclin dependent kinase inhibitor 1A, 1026

N. diseases: 490; N. variants: 17
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE IFNs affect the expression of WAF1 in several cell types, including human melanomas. 9168913 1997
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease LHGDN The results suggest that Tbx2 and Tbx3 may play a dual role during the radial to vertical growth phase transition by both inhibiting senescence via repression of p21(CIP1) expression, and enhancing melanoma invasiveness by decreasing E-cadherin levels. 18829543 2008
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway. 25051367 2014