|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ectopic LKB1 induces growth arrest by upregulating p21/cyclin dependent kinase inhibitor 1A (WAF1) in LKB1 deficient cervical and melanoma cancer cell lines.
|
29963200 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that silencing <i>Myo7a</i> by means of RNAi inhibited melanoma cell growth through upregulation of cell cycle regulator p21 (also known as CDKN1A) and suppressed melanoma cell migration and invasion through downregulation of RhoGDI2 (also known as ARHGDIB) and MMP9.
|
29361540 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sirt1 stable silencing increased <i>Mxd1</i> mRNA expression and led to down-regulation of MYC targets, such as Cdkn1a, Bcl2 and Psen2, whose upregulation is associated with human melanoma aggressiveness and poor prognosis.
|
29383100 |
2017 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CRISPR/Cas9-mediated heterozygous deletion of CDKN1A (encoding p21) or SET8 in melanoma cells demonstrated that the rereplication-mediated cytotoxicity of pevonedistat is mediated through preventing the degradation of p21 and SET8 and is essential for melanoma suppression in nude mice.
|
27333051 |
2016 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway.
|
25051367 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Microarray analysis identified 316 probes whose expression was correlated with G1 checkpoint function in melanoma lines (P≤0.007) including p53 transactivation targets CDKN1A, DDB2, and RRM2B.
|
22540896 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dual suppression of the cyclin-dependent kinase inhibitors CDKN2C and CDKN1A in human melanoma.
|
22997239 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
EZH2 depletion in melanoma cells inhibits cell proliferation, restores features of a cellular senescence phenotype, and inhibits growth of melanoma xenografts in vivo. p21/CDKN1A is activated upon EZH2 knockdown in a p53-independent manner and contributes substantially to cell cycle arrest and induction of a senescence phenotype.
|
21383005 |
2011 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The p53/p21Cip1/ Waf1 pathway mediates the effects of SPARC on melanoma cell cycle progression.
|
20955243 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased p21 protein levels were found in a subset of melanomas.
|
20067556 |
2010 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since AP-2alpha regulates several genes associated with the metastatic potential of melanoma including c-KIT, VEGF, PAR-1, MCAM/MUC18, and p21(Waf1), our data identified CREB as a major regulator of the malignant melanoma phenotype.
|
20805990 |
2010 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These minute tumors exhibited critical signatures of active TGF-beta signaling including high levels of nuclear Smad3 and p21(Waf-1), which are not found in the parental melanomas.
|
19845874 |
2009 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma.
|
18049450 |
2008 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For example, Tbx2 can suppress senescence through a mechanism involving the repression of the cyclin-dependent kinase inhibitors, p19(ARF) and p21(WAF1/CIP1/SDII), and the Tbx2 gene is deregulated in melanoma, breast and pancreatic cancers.
|
17700536 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results suggest that Tbx2 and Tbx3 may play a dual role during the radial to vertical growth phase transition by both inhibiting senescence via repression of p21(CIP1) expression, and enhancing melanoma invasiveness by decreasing E-cadherin levels.
|
18829543 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
The results suggest that Tbx2 and Tbx3 may play a dual role during the radial to vertical growth phase transition by both inhibiting senescence via repression of p21(CIP1) expression, and enhancing melanoma invasiveness by decreasing E-cadherin levels.
|
18829543 |
2008 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Three genes--CDKN1A, DDB2 and ADRB2--exhibited a trend towards loss of expression in melanomas thereby raising the possibility of a linked role in tumorigenesis.
|
16888633 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
P21 and Bax expression in cutaneous malignant melanomas: correlation with histologic prognostic parameters.
|
15743033 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Together, these data strongly suggest that endogenously produced nitric oxide is required for cisplatin-induced p53 activation and p21(Waf1/Cip1/Sdi1) expression, which can regulate melanoma sensitivity to cisplatin.
|
14576150 |
2004 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest a primary role of cyclin-dependent kinase inhibitor genes inactivation in the origin of human melanoma and allow the proposal of new therapeutic strategies based on the transcriptional activation of p21CIP1 gene.
|
12602966 |
2003 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin E, p21(Waf-1) and p27(Kip-1) are also elevated in many primary melanomas, whereas p16(INK4a) is mutated or deleted in many invasive and metastatic melanomas.
|
11602203 |
2001 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
p21CIP1 is dispensable for the G2 arrest caused by genistein in human melanoma cells.
|
10912792 |
2000 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since AP-2 also regulates other genes that are involved in the progression of human melanoma such as c-KIT, E-cadherin, MMP-2, and p21(WAF-1), we propose that loss of AP-2 is a crucial event in the development of malignant melanoma.
|
9632718 |
1998 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IFNs affect the expression of WAF1 in several cell types, including human melanomas.
|
9168913 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results strengthen the evidence for the presence of a melanoma metastasis suppressor gene on chromosome 6. neo6/MelJuSo hybrids expressed 2.4- to 3.4-fold more of the melanoma differentiation-associated gene mda-6 (previously shown to be identical to WAF1/CIP1/Sdi1/CAP20) than parental metastatic cells. mda-6/WAF1 is among the candidate genes on chromosome 6.
|
8634087 |
1996 |