|
Abnormality of the urinary system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acoustic Neuroma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Aggressive vestibular schwannomas showing postoperative rapid growth - their association with decreased p27 expression.
|
16283443 |
2005 |
|
Acromegaly
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Early onset acromegaly associated with a novel deletion in CDKN1B 5'UTR region.
|
25645465 |
2015 |
|
Acromegaly
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
To date, the number of molecular genetic factors unequivocally linked to pituitary tumours can be counted on the fingers of one hand: (1) GNAS1 activation in acromegaly; (2) the MENIN and p27Kip1 (CDKN1B) mutations associated with multiple endocrine neoplasia type 1; (3) mutations of PRKA1RA with loss of 17q22-24 in Carney complex, and (4) aryl hydrocarbon receptor interacting protein gene mutations in 15% of familial isolated pituitary adenomas and 50% of familial isolated acromegaly.
|
21778740 |
2011 |
|
Acromegaly
|
0.030 |
Biomarker
|
disease |
BEFREE |
The relatively high age at diagnosis, as well as its sporadic presentation, suggests that these patients are carriers of mutations with reduced pathogenicity. p27(KIP1) is unlikely to represent the common unifying nonendocrine etiology for acromegaly and cancer.
|
20530095 |
2010 |
|
ACTH-Secreting Pituitary Adenoma
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute kidney injury
|
0.200 |
Biomarker
|
disease |
RGD |
Role of caspases on cell death, inflammation, and cell cycle in glycerol-induced acute renal failure.
|
16557226 |
2006 |
|
Acute lymphocytic leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
No mutations in either TEL or KIP1 were found; this suggest that neither TEL nor KIP1 is the critical 12p tumor suppressor gene in childhood ALL.
|
8640833 |
1996 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Thus, the present study documents the loss of both ETV6 and CDKN1B genes accompanying the occurrence of a complex rearrangement involving chromosomes 3 and 12 in a case of childhood ALL.
|
19963112 |
2009 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1.
|
8605354 |
1996 |
|
Acute lymphocytic leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Its recent assignment to the chromosomal region (12p12.3) prompted us to study the p27KIP1 gene in a series of 61 children with ALL.
|
7579355 |
1995 |
|
Acute monocytic leukemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this study, the expression of these markers and of EVI1 and CDKN1B was determined using oligonucleotide microarrays in 286 AML comprising all cytogenetic groups.
|
22072540 |
2012 |
|
Acute monocytic leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
ETV6 and CDKN1B had reduced expression levels in CK-AML patients with deletion in 12p13 as compared to CK-AML without deletion in 12p13, while the other genes (BCL2L14, LRP6, DUSP16 and GPRC5D) located within the minimal deleted region in 12p13 had very low or missing expression in CK-AML irrespective of their copy number status.
|
25213837 |
2014 |
|
Acute monocytic leukemia
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
Absence of p21(CIP 1), p27(KIP 1) and p 57(KIP 2) methylation in MDS and AML.
|
15936816 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of p21Cip1 or p27Kip1 in the promyelocytic leukemia cell line HL60 accelerates its lineage-specific differentiation.
|
10697493 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest a sequential molecular mechanism from MYC reduction, SKP2 reduction, Cdkn1b protein stabilization, G1 phase arrest to granulocytic differentiation by KRGE in human APL.
|
24095829 |
2013 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Loss of p27 expression is associated with poor prognosis in stage I-II pancreatic cancer.
|
14707458 |
2003 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, Cks1 mRNA expression had no such relationship with p27(Kip1), although Cks1 mRNA was significantly elevated in adenocarcinomas.
|
12670508 |
2003 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, in a series of gastric adenocarcinomas we studied the association of p27(KIP1) expression with H. pylori genotype (vacA, cagA, cagE and virB11) and the involvement of C-MYC in this process.
|
20059402 |
2010 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, we studied the expression of p16MTS1, p21WAF1, and p27KIP1 by immunohistochemistry in 60 cervical adenocarcinomas.
|
11499840 |
2001 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas.
|
14614018 |
2003 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, retention of CDK4 in these TA-like pituitary cells synergizes with loss of p27(Kip1) to induce pituitary adenocarcinomas.
|
18172308 |
2008 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
LHGDN |
Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage.
|
15014027 |
2004 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage.
|
15014027 |
2004 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Paradoxical expression of cell cycle inhibitor p27 in endometrioid adenocarcinoma of the uterine corpus - correlation with proliferation and clinicopathological parameters.
|
12085261 |
2002 |