|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
Cyclin-dependent kinase inhibitor 1B (CDKN1B) was identified as a direct target of negative regulation by miR-222-3p in NP cells, and expression of miR-222-3p was found to be negatively correlated with that of CDKN1B in IDD tissue.
|
30984546 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the existence of regulatory networks involving SNHG1, the miR-221/222 cluster and the cyclin-dependent kinase inhibitor 1B (CDKN1B/p27)/mammalian target of rapamycin (mTOR) signaling pathway in PD.
|
31499060 |
2019 |
|
Intervertebral disc disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Cyclin-dependent kinase inhibitor 1B (CDKN1B) was identified as a direct target of negative regulation by miR-222-3p in NP cells, and expression of miR-222-3p was found to be negatively correlated with that of CDKN1B in IDD tissue.
|
30984546 |
2019 |
|
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeting of CDKN1B by miR-222-3p may contribute to the development of intervertebral disc degeneration.
|
30984546 |
2019 |
|
Post MI
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In our previous study, the haploinsufficiency of p27kip1 (p27) was demonstrated to improve cardiac function in mice post‑MI by promoting angiogenesis and myocardium protection through the secretion of growth factors.
|
31485654 |
2019 |
|
Advanced Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present study finds that CAF-derived exosomal miR-196a confers cisplatin resistance in HNC by targeting CDKN1B and ING5, indicating miR-196a may serve as a promising predictor of and potential therapeutic target for cisplatin resistance in HNC.
|
30642385 |
2019 |
|
Metastatic human epidermal growth factor 2 positive carcinoma of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that CDKN1B and JAK2, if validated, may serve as prognostic factors potentially implicated in T resistance, which seems to be associated with distinct pathways in de novo and R-MBC.
|
30877976 |
2019 |
|
Graves Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with GD who underwent radioiodine therapy (RIT) had a lower lymphocytic expression level of p27Kip1, and those who took beta-blockers had higher expression levels of BID (<i>BH3</i>-interacting domain) and a lower Ki-67 expression level in thyrocytes than those who did not.
|
30018638 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among female patients, 63% never consumed tobacco, and the most frequent clinical phenotype was asthma combined with COPD; female patients visited the family doctor sooner after AECOPD than men (4 vs 7 days).
|
30075531 |
2018 |
|
Polycystic Ovary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Long non-coding RNA LINC-01572:28 inhibits granulosa cell growth via a decrease in p27 (Kip1) degradation in patients with polycystic ovary syndrome.
|
30293818 |
2018 |
|
Squamous cell carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
It was concluded that miR-452-5p may serve an essential role in the occurrence and progression of LUSC by targeting CDKN1B, which is involved in the cell cycle.
|
29616113 |
2018 |
|
Hypocalciuric hypercalcemia, familial, type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
The phenotypes and outcome of MEN1-, MEN4- and HRPT2-related HPTH are briefly described, with a focus on the most recent literature data and is compared with familial hypocalciuric hypercalcemia.
|
28874394 |
2018 |
|
Decompensated cardiac failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We screened 234 consecutive patients admitted with decompensated heart failure; 46 patients (42 men/4 women; 61 ± 12 years of age) were randomized to a moderate intensity aerobic interval training ( n = 24) or to a control group ( n = 22).
|
28782380 |
2018 |
|
COPD exacerbation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Among female patients, 63% never consumed tobacco, and the most frequent clinical phenotype was asthma combined with COPD; female patients visited the family doctor sooner after AECOPD than men (4 vs 7 days).
|
30075531 |
2018 |
|
Gastric Neuroendocrine Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Twenty-two studies using a range of methodologies with different normalization protocols were identified: tumor - gastric NET type 1 (n = 1 study: MiR-222, regulates p27KIP1), pancreatic (n = 6: MiR-21 [inflammatory marker, oncogene] and MiR-144 [PI3K/AKT signaling], both up- and downregulated depending on the method), small intestinal (n = 7: no consistent signature), and colorectal (n = 3: no consistent signature); blood - gastric NET type 1 (n = 1: MiR-222), pancreatic (n = 3: MiR-21), and small intestinal (n = 3: no consistent signature).
|
29566385 |
2018 |
|
Crohn Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Up-regulated CRM1 may facilitate IEC apoptosis possibly through p27kip1 in CD, indicating an important role of CRM1 in the pathophysiology of CD.
|
28286054 |
2017 |
|
HIV Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The annual rate of diagnosis of HIV infection among Hispanics or Latinos is three times that of non-Hispanic whites (3), and a recent study found increases in incidence of HIV infection among Hispanic or Latino men who have sex with men (4).
|
29023431 |
2017 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Inconsistent with a role limited to cell cycle arrest the acute stimuli, voluntary wheel running (RUN), environmental enrichment (ENR) and kainate-induced seizures increased p27kip1 expressing cells.
|
27790794 |
2017 |
|
Papillary Thyroid Microcarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In subgroup analysis, the rates of p27kip1 expression loss were 0.683, 0.393, and 0.414 in the classical variant, follicular variant, and papillary thyroid microcarcinoma, respectively.
|
27834461 |
2017 |
|
High-Risk Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further investigation into this HR-NB-specific ESC-like signature in 295 and 243 independent patients revealed and validated the general prognostic index of CDK2 and CDKN3 compared with CDKN2D and CDKN1B.
|
28246384 |
2017 |
|
Endocrine Gland Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Subsequently, germline mutations in the human ortholog CDKN1B were also found in a subset of patients with a MEN-like phenotype and this led to the identification of MEN4.
|
26184857 |
2016 |
|
Disorder of eye
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, we suggest that seven crucial genes, including Cdkn1b, Acta1 and Tnnt3, play important roles in the progression of eye disorders such as glaucoma.
|
27121343 |
2016 |
|
Pituitary Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
P27/CDKN1B Translational Regulators in Pituitary Tumorigenesis.
|
27824399 |
2016 |
|
Agenesis of corpus callosum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD133(+)ACC cells produced activated NOTCH1 (N1ICD) and generated CD133(-)cells that expressed JAG1 as well as neural differentiation factors NR2F1, NR2F2, and p27Kip1.
|
27084744 |
2016 |
|
Aplasia Cutis Congenita
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CD133(+)ACC cells produced activated NOTCH1 (N1ICD) and generated CD133(-)cells that expressed JAG1 as well as neural differentiation factors NR2F1, NR2F2, and p27Kip1.
|
27084744 |
2016 |