melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, a series of functional assays demonstrated that mir-221 could directly inhibit cKit, p27(Kip1) and, possibly, other pivotal proteins in melanoma.
|
19126397 |
2009 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reduced Cks1 or Skp2 expression and enhanced p27(Kip1) levels inhibit melanoma cell growth.
|
16924241 |
2007 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Here we provide evidence that p15(INK4b), rather than p27(KIP1), is the cyclin-dependent kinase inhibitor responsible for G0/G1 arrest of human melanoma cells grown on fibrillar collagen.
|
17553787 |
2007 |
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
Reduced expression of p16 and p27 is correlated with tumour progression in cutaneous melanoma.
|
18027257 |
2007 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review summarises the current knowledge of alterations in these two pathways at G1/S transition and specifically the role of the key cell cycle regulatory proteins pRb, p16INK4a (p16), cyclin D1, p27Kip1 (p27), p53 and p21Waf1/Cip1 (p21) in the pathogenesis of melanoma.
|
16916716 |
2006 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, adhesion-growth factor cooperation, leading to efficient activation of ERK, regulates cyclin D1 and p27Kip1 levels in human melanocytes and mutant BRAF overrides adhesion-growth factor control of these two G1 cell cycle proteins in melanomas.
|
15735667 |
2005 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
We therefore examined by immunohistochemistry the expression of Skp2, p27KIP1 and Ki-67 in 10 naevi (Ns), 15 superficial spreading melanomas (SSMs), 10 nodular melanomas (NMs) and 14 melanoma metastases (Ms).
|
15736055 |
2005 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Expression of p27 and MAPK proteins involved in all-trans retinoic acid-induced apoptosis and cell cycle arrest in matched primary and metastatic melanoma cells.
|
15492811 |
2004 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Expression of cell cycle inhibitor p27Kip1 and its inactivator Jab1 in melanocytic lesions.
|
15154004 |
2004 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our data shows that loss of p27KIP1 protein expression and LOH at 12p13 contribute to tumour progression in melanoma.
|
15205952 |
2004 |
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cyclin E, p21(Waf-1) and p27(Kip-1) are also elevated in many primary melanomas, whereas p16(INK4a) is mutated or deleted in many invasive and metastatic melanomas.
|
11602203 |
2001 |
melanoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Collectively, our data suggest that DNA methylation may be a cause of monoallelic p27Kip1 silencing in malignant melanoma, which would support a role for p27Kip1 haploinsufficiency in human cancer.
|
11042700 |
2000 |
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we utilized an adenoviral vector-based expression system to examine the consequences of p27Kip1 overexpression in the human carcinoma cell lines A549, HeLa and RKO, in human melanoma SK-MEL-110 cells, in human lung fibroblasts IMR90 and in the rat fibroblast line Rat1.
|
9416843 |
1997 |