Our findings indicate that a loss of Sig1R function is causative for ALS16, and collapse of the MAM is a common pathomechanism in both Sig1R- and SOD1-linked ALS Furthermore, our discovery of the selective enrichment of IP<sub>3</sub>R3 in motor neurons suggests that integrity of the MAM is crucial for the selective vulnerability in ALS.
Our findings indicate that a loss of Sig1R function is causative for ALS16, and collapse of the MAM is a common pathomechanism in both Sig1R- and SOD1-linked ALS Furthermore, our discovery of the selective enrichment of IP<sub>3</sub>R3 in motor neurons suggests that integrity of the MAM is crucial for the selective vulnerability in ALS.