SEMA3A, semaphorin 3A, 10371

N. diseases: 202; N. variants: 19
Disease: Diabetic Nephropathy ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.030 Biomarker disease BEFREE Altogether, these findings manifested that miR-15b-5p protectively antagonized HG-triggered podocyte damage through relieving HG-induced apoptosis, oxidative stress, and inflammatory process in podocytes by targeting Sema3A, suggesting that miR-15b-5p might be a new therapeutic agent to improve management of DN. 31025335 2019
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.030 Biomarker disease BEFREE We have shown that Sema3A regulates podocyte shape and that excess Sema3A signaling induces glomerular disease and aggravates diabetic nephropathy. 27787866 2017
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.030 Biomarker disease BEFREE Diabetic Sema3a(+) mice develop massive proteinuria, renal insufficiency, and extensive nodular glomerulosclerosis, mimicking advanced DN in humans. 25475434 2015