SEMA3A, semaphorin 3A, 10371

N. diseases: 202; N. variants: 19
Disease: Nodule ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028259
Disease: Nodule
Nodule 		0.020 AlteredExpression phenotype BEFREE The results from the alkaline phosphatase assay, calcium nodule staining and the analysis of the osteogenic gene expression revealed that Sema3A inhibits osteogenic differentiation of MG63 cells in single‑cell culture and promotes osteogenic differentiation of MG63 cells in co‑culture with Schwann cells, in a concentration‑dependent manner. 29484438 2018
CUI: C0028259
Disease: Nodule
Nodule 		0.020 AlteredExpression phenotype BEFREE In contrast, Sema3A overexpression reduced the ability of KHOS cells to cause ectopic bone formation in mice and to increase bone nodule formation by engaging DKK1/β-catenin signalling. 29720701 2018