|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
8/13 were OBI, harboring at least one OBI-signature S protein mutation.
|
29263533 |
2019 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Occult HBV infection in Chinese blood donors: role of N-glycosylation mutations and amino acid substitutions in S protein transmembrane domains.
|
31516090 |
2019 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
A nonsense mutant of the hepatitis B virus large S protein antagonizes multiple tumor suppressor pathways through c-Jun activation domain-binding protein1.
|
30870427 |
2019 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Altogether, specific domains and residues in the HBV S protein that are required for oligomerization and SVP generation were defined.<b>IMPORTANCE</b> The small hepatitis B virus envelope protein S has the intrinsic ability to direct the morphogenesis of spherical 20-nm subviral lipoprotein particles.
|
29540592 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis B virus (HBV) expresses three co-terminal envelope proteins: large (L), middle (M), and small (S), with the S protein driving the secretion of both virions and subviral particles.
|
29604477 |
2018 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, the elicited antibodies were able to neutralize HBV infection in an NTCP-expressing infection system (HepG2-NTCP cell line) more efficiently than those induced by mice fed on Lactuca sativa expressing the S protein.
|
30082163 |
2018 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The potential role of specific amino acid substitutions in the S protein from OBI in HBsAg production and excretion was examined in vitro.
|
23658444 |
2013 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
That there were few S protein substitutions suggests a minor role of the host immune defenses in OBI occurrence.
|
21411575 |
2011 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the specific and cross-reactive CD8 T cell immunity to three natural variants (of different geno/serotype) of the small hepatitis B surface Ag (or S protein).
|
16547235 |
2006 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
S4 and S5.1 of genotype A had the characteristic nucleotide deletions in core and pre-S1 region seen in genotype D. The major observations in patients with occult HBV infection were as follows: frequent quasispecies variation, deletions in pre-S2/S region affecting the surface promoters (nt 3025-54) and pre-S protein (S3, S5, S6, S8), truncated precore (S6, S8, S7.1) and core (S9) owing to stop signal, alternate start codon for the Polymerase gene (S3, S9), and YMDD mutation (S1, S4, S9) in patients not on antiviral therapy.
|
15521005 |
2004 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The secretion block resulted from mutations in the S protein, including the Gly145Arg substitution known to emerge under antibody to hepatitis B surface antigen immunoglobulin treatment.
|
14517791 |
2003 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The delay in HBV infection recurrence was proportional to the number of pre-LT HBV mutations in the pre-S2 and S genes: the higher the number, the longer the interval between LT and recurrence of infection (pre-S2, P =.0124; S, P =.0060; total number of mutations in S protein, P =.0421).
|
12004344 |
2002 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Eleven neonates were positive for HBV infection, and two of them showed point mutations that might have rendered the virus resistant to the vaccine, possibly due to a change in the S protein's secondary structure.
|
9763505 |
1998 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
An attenuated strain of Salmonella typhi delta(cya) delta(crp-cdt) delta(asd) expressing a gene encoding a hepatitis B virus core-pre-S protein was tested in female adult volunteers for its ability to elicit a systemic and a mucosal immune response.
|
8945569 |
1996 |
|
Hepatitis B
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been clearly shown that the region between residues 120 and 150 of the S protein represents the a determinants common to all hepatitis B virus (HBV) isolates and is exposed on the surface of the HBV particle.
|
8666522 |
1995 |
|
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DNA sequence analysis of both primate and patient liver hepatitis B virus confirmed the presence of the DNA encoding the S protein variant and associates this DNA with the predominant hepatotropic virus in liver infection.
|
1568715 |
1992 |