Disease: Influenza A ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 Biomarker disease BEFREE Herein, macrophages isolated from IFITM3-deficient mice were more susceptible to initial IAV infection, but late-stage viral replication was still controlled through abortive infection. 31731106 2020
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 Biomarker disease BEFREE By applying an iterative approach for the cluster definition and computational cluster analysis, we found that IFITM3 reorganizes into clusters as IAV infection progresses. 31212878 2019
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 PosttranslationalModification disease BEFREE However, infection by either Vesicular Stomatitis Virus (VSV) or Influenza A Virus (IAV) triggers methylation of IFITM3 by promoting its disassociation from LSD1. 29281729 2017
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 GeneticVariation disease BEFREE These results suggest that the IFITM3 genotype may not be a determinant of disease severity of IAV infection. 28813716 2017
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 Biomarker disease BEFREE We show that rhesus macaque (rh) IFITM3 inhibits SIV and FLUAV entry in cell culture, although with moderately reduced efficiency as compared to its human counterpart. 28257482 2017
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 GeneticVariation disease BEFREE Hospitalization Risk Due to Respiratory Illness Associated with Genetic Variation at IFITM3 in Patients with Influenza A(H1N1)pdm09 Infection: A Case-Control Study. 27351739 2016
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 GeneticVariation disease BEFREE IFITM3 polymorphism rs12252-C restricts influenza A viruses. 25314048 2014
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 Biomarker disease BEFREE IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. 24699674 2014
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 Biomarker disease BEFREE The chicken IFITM3 protein restricts cell infection by influenza A viruses and lyssaviruses to a similar level as its human orthologue. 24067955 2013
CUI: C2062441
Disease: Influenza A
Influenza A 		0.100 Biomarker disease BEFREE Using a knockout mouse model, we now test this hypothesis directly and find that IFITM3 is essential for defending the host against influenza A virus in vivo. 22446628 2012