|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Two variants, 6q25.1-rs9383938 and TXNRD2-rs8141691, were statistically significantly associated with percent MD (P = 0.019 and 0.03, respectively), with the 6q25.1-rs9383938 association being consistent with the SNP effect on breast cancer risk.
|
25002657 |
2014 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
In this study we evaluated possible associations between breast cancer risk and survival and single nucleotide polymorphisms (SNPs) in the selenoprotein genes GPX1, GPX2, GPX3, GPX4, SELS, SEP15, SEPN1, SEPP1, SEPW1, TXNRD1, and TXNRD2 among Hispanic/Native American (2111 cases, 2597 controls) and non-Hispanic white (NHW) (1481 cases, 1586 controls) women in the Breast Cancer Health Disparities Study.
|
24278290 |
2013 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
This was confirmed in another sample cohort of 283 BC survivors, and rs1139793 was found significantly associated with mRNA expression level of TXNRD2 in blood.
|
23597419 |
2013 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
Cell-based studies with a breast cancer cell line (T47D cells) showed that thyroid hormone (T3) repressed STAT5 signaling in TRβ-expressing cells through decreasing STAT5-mediated transcription activity and target gene expression, whereas sustained STAT5 signaling was observed in TRβPV-expressing cells.
|
21399657 |
2011 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
We measured differential allelic expression of 12 candidate genes possibly related to breast cancer susceptibility (BRCA1, BRCA2, C1qA, CCND3, EMSY, GPX1, GPX4, MLH3, MTHFR, NBS1, TP53 and TRXR2) in breast tissue (n = 40) and fresh blood (n = 170) of healthy individuals and EBV-transformed lymphoblastoid cells (n = 19).
|
20003265 |
2009 |
|
Breast Carcinoma
|
0.070 |
Biomarker
|
disease |
BEFREE |
We examined associations between 54 polymorphisms that tag the known common variants (minor allele frequency > 0.05) in 10 genes involved in oxidative damage repair (CAT, SOD1, SOD2, GPX1, GPX4, GSR, TXN, TXN2, TXNRD1, and TXNRD2) and survival in 4,470 women with breast cancer.
|
17634480 |
2007 |
|
Breast Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
For TXNRD2 A66S [AS versus AA: odds ratio (OR), 1.05; 95% confidence intervals (95% CI), 0.96-1.15; SS versus AA: OR, 1.12; 95% CI, 0.98-1.29], there are bioinformatics data to suggest that it is functional but confirmation in independent data sets is required before they can be regarded as definitive breast cancer susceptibility alleles.
|
16424062 |
2006 |