|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Targeting TRIM3 deletion-induced tumor-associated lymphangiogenesis prohibits lymphatic metastasis in esophageal squamous cell carcinoma.
|
30542119 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bioinformatics analysis predicted that tripartite motif-containing 3 (TRIM3), a tumor suppressor gene in cervical cancer, is a promising target of miR-454-3p.
|
31270028 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The effects of TRIM3 overexpression or knockdown on gastric cancer growth and metastasis in vivo were investigated by using subcutaneous xenograft tumor and peritoneal metastasis mouse model.
|
30031392 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The TRIM3 overexpression weakened cell viability, and promote apoptosis of C-33A and SiHa cells in vitro, and inhibit tumor growth in vivo, which suggested that TRIM3 could reduce proliferation of cervical cancer cells.
|
29524410 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of TRIM3 on tumor growth and metastases in nude mice was also investigated.
|
28950898 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we found that the expression of tripartite motif-containing protein 3 (TRIM3), a candidate tumor suppressor gene, was lower in synovial tissue samples of RA patients than in that of healthy controls.
|
28259936 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the potential role of TRIM3 as a tumour suppressor in CRC development by manipulating the expression of TRIM3 in two authentic CRC cell lines, HCT116 and DLD1, followed by various functional assays, including cell proliferation, colony formation, scratch wound healing, soft agar, and invasion assays.
|
26691157 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that TRIM3 acts as a tumor suppressor in GBM by restoring asymmetric cell division.
|
24947043 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, we conclude that TRIM3 is a tumor suppressor mapping to chromosome 11p15.5 and that it might block tumor growth by sequestering p21 and preventing it from facilitating the accumulation of cyclin D1-cdk4.
|
23318451 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Clinicopathological analysis revealed that low TRIM3 expression was significantly correlated with tumor size (p = 0.034), histological grade (p < 0.001), serum AFP (p = 0.025), and TNM stage (p = 0.021).
|
24994609 |
2014 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of tripartite motif-containing 3 (TRIM3) has been reported to be involved in the pathogenesis of human glioblastoma.
|
28950898 |
2017 |
|
Glioblastoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Tripartite motif (TRIM3) is recently identified as a tumour suppressor in glioblastoma but this tumour-suppressive function has not been investigated in CRC.
|
26691157 |
2016 |
|
Glioblastoma
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Loss of heterozygosity of the TRIM3 locus in ∼20% of human glioblastomas raised the possibility that this NHL-domain containing member of the TRIM gene family might be a mammalian tumor suppressor.
|
23318451 |
2014 |
|
Glioblastoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
TRIM3 expression attenuates stem-like qualities of primary GBM cultures, including neurosphere formation and the expression of stem cell markers CD133, Nestin, and Nanog.
|
24947043 |
2014 |
|
Adult Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of tripartite motif-containing 3 (TRIM3) has been reported to be involved in the pathogenesis of human glioblastoma.
|
28950898 |
2017 |
|
Childhood Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of tripartite motif-containing 3 (TRIM3) has been reported to be involved in the pathogenesis of human glioblastoma.
|
28950898 |
2017 |
|
Glioblastoma Multiforme
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of tripartite motif-containing 3 (TRIM3) has been reported to be involved in the pathogenesis of human glioblastoma.
|
28950898 |
2017 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Tripartite motif (TRIM3) is recently identified as a tumour suppressor in glioblastoma but this tumour-suppressive function has not been investigated in CRC.
|
26691157 |
2016 |
|
Childhood Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Tripartite motif (TRIM3) is recently identified as a tumour suppressor in glioblastoma but this tumour-suppressive function has not been investigated in CRC.
|
26691157 |
2016 |
|
Glioblastoma Multiforme
|
0.030 |
Biomarker
|
disease |
BEFREE |
Tripartite motif (TRIM3) is recently identified as a tumour suppressor in glioblastoma but this tumour-suppressive function has not been investigated in CRC.
|
26691157 |
2016 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma.
|
24947043 |
2014 |
|
Childhood Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Human Brat ortholog TRIM3 is a tumor suppressor that regulates asymmetric cell division in glioblastoma.
|
24947043 |
2014 |
|
Glioblastoma Multiforme
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
TRIM3 expression attenuates stem-like qualities of primary GBM cultures, including neurosphere formation and the expression of stem cell markers CD133, Nestin, and Nanog.
|
24947043 |
2014 |
|
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings demonstrated miR-454-3p as a cancer promoter by targeting TRIM3 in human cervical cancer.
|
31270028 |
2019 |
|
Cervix carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings demonstrated miR-454-3p as a cancer promoter by targeting TRIM3 in human cervical cancer.
|
31270028 |
2019 |