|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
After DEN injection, CXCR6-deficient mice had a significantly higher tumor burden than WT mice and increased tumor progression, characterized by reduced intrahepatic numbers of invariant NKT and CD4<sup>+</sup> T cells that express tumor necrosis factor and interferon gamma.
|
30710528 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The oncoprotein Smoothened (SMO), a G-protein-coupled receptor (GPCR) of the Frizzled-class (class-F), transduces the Hedgehog signal from the tumour suppressor Patched-1 (PTCH1) to the glioma-associated-oncogene (GLI) transcription factors, which activates the Hedgehog signalling pathway<sup>1,2</sup>.
|
31168089 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD97 Promotes Tumor Aggressiveness Through the Traditional G Protein-Coupled Receptor-Mediated Signaling in Hepatocellular Carcinoma.
|
29704239 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, as key regulators of tumorigenesis and development, YAP/TAZ are phosphorylated and regulated by multiple molecules and pathways including Lats1/2 of Hippo, Wnt and G-protein-coupled receptor (GPCR) signaling, with a regulatory role in cell physiology, tumor cell development and pathological abnormalities simultaneously.
|
29749524 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NF-κB is suppressed by NF2/merlin, yet it is mutated or repressed in schwannomas, and therefore MCP-1/CCL2, MIP-1α/CCL3, CXCL16, and CXCR6/Bonzo are likely expressed in these tumors.
|
29117601 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCR6 promotes tumor cell proliferation and metastasis in osteosarcoma through the Akt pathway.
|
27823764 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here, we aimed to identify a treatment to normalize tumoral vessels and restore normal blood perfusion in tumor tissue with a Vegf receptor inhibitor and/or a ligand of dopamine G protein-coupled receptor D2 (D2R).
|
28152577 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Survival analysis showed that large tumor size (>5 cm), elevated preoperative serum carcinoembryonic antigen (CEA) level, advanced TNM stage and high CXCR6 expression indicated worse overall survival (OS) and disease-free survival (DFS) in GC, and CXCR6 was an independent predictor for both OS and DFS in GC.
|
28440473 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Pancreatic ductal adenocarcinoma (PDAC) is characterized by high expression of transforming growth factor (TGF)-β and the G protein-coupled receptor proteinase-activated receptor 2 (PAR2), the latter of which functions as a cell-surface sensor for serine proteinases asscociated with the tumour microenvironment.
|
27248167 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of the calcium-sensing receptor (CaSR), a calcium-binding G protein-coupled receptor is downregulated in CRC leading us to hypothesize that the CaSR has tumor suppressive roles in the colon.
|
25701758 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Further, this paper will examine the relationship of WT1 with CD97, a gene that codes for an epidermal growth factor receptor family member, an adhesion G-protein-coupled receptor, thought to promote tumor invasiveness and migration.
|
25434383 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies demonstrated that tissue factor (TF) combined with coagulation factor VII (FVII) has a pathological role by activating a G-protein-coupled receptor called protease-activated receptor 2 (PAR2) for tumor growth.
|
24853422 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The endothelin-1 (ET-1)/endothelin A receptor (ETAR, a G protein-coupled receptor) axis confers pleiotropic effects on both tumor cells and the tumor microenvironment, modulating chemo-resistance and other tumor-associated processes by activating Gαq- and β-arrestin-mediated pathways.
|
25194819 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, we show in both cell culture and human tumors that cancer-associated Gq/11 mutants activate YAP, a major effector of the Hippo tumor suppressor pathway that is also regulated by G protein-coupled receptor signaling.
|
24882516 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CD97 is a tumor-associated adhesion-class G-protein-coupled receptor involved in modulating cell migration.
|
25174588 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
G protein-coupled receptor family C group 5 member A (GPRC5A), a member of G protein-coupled receptor family, has been shown to function as a tumor suppressor in lung tissue.
|
23651229 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The chemokine receptor CXCR7, belonging to the membrane-bound G protein-coupled receptor superfamily, is expressed in several tumor types.
|
23979133 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, an unsulfated vGPCR mutant (yydd-vGPCR) attenuated the tumor growth triggered by hGRO-α.
|
23269549 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistic investigations revealed that RGS4 reduced vGPCR-enhanced cell proliferation, migration, VEGF expression, and Akt activation and suppressed tumor formation induced by vGPCR.
|
22942256 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Reduction of CXCR6 or its ligand CXCL16 in cancer cells reduced cell invasion in vitro and tumor growth, angiogenesis, and metastases in vivo.
|
22710437 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Raf kinase trapping to Golgi (RKTG) is a potential tumor suppressor gene due to its negative roles in regulating Ras/Raf/MEK/ERK (extracellular signal-regulated kinase) pathway and GPCR (G protein-coupled receptor) Gβγ subunit signaling.
|
21385899 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a mouse allograft model for KS, specific inhibition of the paracrine activation of mTOR in non-vGPCR-expressing cells was sufficient to inhibit HIF upregulation in these cells, and abolished the ability of the vGPCR-expressing cells to promote tumor formation in vivo.
|
21559457 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that expression of sphingosine-1-phosphate receptor-1 (S1PR1), a G protein-coupled receptor for the lysophospholipid sphingosine-1-phosphate (S1P), is elevated in STAT3-positive tumors.
|
21102457 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
T-cell death-associated gene 8 (TDAG8) is an extracellular pH-sensing G protein-coupled receptor that is overexpressed in various tumors and tumor cell lines.
|
20855608 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
CXCR6-deficient mice showed reduced infiltration of tumors by activated CD8 T cells and impaired tumor regression following treatment with local IR to the tumor and Abs blocking the negative regulator of T cell activation, CTLA-4.
|
18713980 |
2008 |