DLL3, delta like canonical Notch ligand 3, 10683

N. diseases: 134; N. variants: 9
Disease: Neuroendocrine Tumors ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors 		0.040 AlteredExpression group BEFREE We studied the expression of DLL3, its reproducibility and prognostic role in pulmonary neuroendocrine tumors. 31447005 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors 		0.040 AlteredExpression group BEFREE Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand that is highly expressed in SCLC and other neuroendocrine tumors but minimally expressed in normal tissues. 31215500 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors 		0.040 Biomarker group BEFREE In this study, the expression of DLL3 was analyzed using different DLL3 antibodies in high-grade neuroendocrine tumors of the lung and cell cultures. 31109352 2019
CUI: C0206754
Disease: Neuroendocrine Tumors
Neuroendocrine Tumors 		0.040 Biomarker group BEFREE In addition, we illustrate how the development of promising therapeutic strategies based on the identification of molecular targets (mTOR inhibitors in carcinoids and targeting of the Notch ligand DLL3 in SCLC) may require the assessment of predictive biomarkers, even in the group of neuroendocrine tumours of the lung. 29239031 2018