OGA, O-GlcNAcase, 10724

N. diseases: 140; N. variants: 6
Disease: Diabetes ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE OGA mRNA levels were also increased in leucocytes from patients with diabetes and were correlated with mRNA coding for two pro-inflammatory proteins, TNFα and TxNIP.Therefore, OGA activity in leucocytes might be a more easily accessible biomarker than OGA expression levels. 29890544 2019
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE Disruptions in the cycling of O-GlcNAc mediated by O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA), respectively, is a driving force for aberrant cell signaling in disease pathologies, such as diabetes, obesity, Alzheimer's disease, and cancer. 30237786 2018
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 GeneticVariation disease BEFREE Although the Oga gene (MGEA5) is a documented human diabetes susceptibility locus, its role in maintaining insulin-glucose homeostasis is unclear. 25596529 2015
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 GeneticVariation disease BEFREE These results suggest that this variant within the MGEA5 gene may increase diabetes risk in Mexican Americans. 15793264 2005