OGA, O-GlcNAcase, 10724

N. diseases: 140; N. variants: 6
Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 Biomarker disease BEFREE Enzymatic activities of GCase, β-hexosaminidase, and cathepsin D were measured in the frontal cortex, putamen, and substantia nigra (SN) of a cohort of patients with advanced PD and DLB as well as age-matched non-demented controls (n = 15/group) using fluorometric assays. 29948939 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 AlteredExpression disease BEFREE The β-galactosidase to α-galactosidase and β-hexosaminidase to β-galactosidase activity ratios were more useful for distinguishing PD and PS patients from NCs (P < 0.0001). 30415794 2019
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 AlteredExpression disease BEFREE Leukocyte glucocerebrosidase and β-hexosaminidase activity in sporadic and genetic Parkinson disease. 26705847 2016
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.040 AlteredExpression disease BEFREE In the PD group, β-glucocerebrosidase activity was reduced (P < 0.05) and patients at earlier stages showed lower enzymatic activity (P < 0.05); conversely, β-hexosaminidase activity was significantly increased (P < 0.05). 24436092 2014