SIX2, SIX homeobox 2, 10736

N. diseases: 79; N. variants: 1
Disease: Cleft Palate-Lateral Synechia Syndrome ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0795898
Disease: Cleft Palate-Lateral Synechia Syndrome
Cleft Palate-Lateral Synechia Syndrome 		0.010 GeneticVariation disease BEFREE We found that Six1 <sup>-/-</sup> Six2 <sup>-/-</sup> double-mutant mice were born with severe craniofacial deformity not seen in the Six1 <sup>-/-</sup> or Six2 <sup>-/-</sup> single mutants, including skull bone agenesis, midline facial cleft, and syngnathia. 30905259 2019