HPSE, heparanase, 10855

N. diseases: 393; N. variants: 12
Disease: Bladder Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.030 AlteredExpression disease BEFREE Therefore, berberine inhibits the metastasis and invasion of bladder cancer cell, possibly via blocking the heparanase expression and thus may be used clinically to reduce the recurrence of bladder cancer. 23065570 2013
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.030 PosttranslationalModification disease LHGDN In the total series of bladder cancer and normal bladder samples, the combination of promoter CpG methylation and EGR1 expression regulated heparanase expression in a stepwise manner, where heparanase expression was the lowest in methylation-positive and EGR1-negative samples and the highest in methylation-negative and EGR1-positive samples. 16007175 2005
CUI: C0005695
Disease: Bladder Neoplasm
Bladder Neoplasm 		0.030 AlteredExpression disease BEFREE The heparanase gene and protein showed similar patterns of expression in bladder cancer. 11547059 2001