melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A multifactorial analysis using Cox's regression model revealed that β-catenin, lymphoid enhancer-binding protein-1, heparanase-1, and the TNM stage were all independent factors in malignant melanoma (risk ratios were 7.294, 5.550, 5.622, and 4.794; p-values were 0.007, 0.018, 0.018, and 0.029, respectively).
|
25343173 |
2015 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the relevance of the dual functions of HPSE to malignant melanoma in vitro, as well as in different mouse melanoma models based on the intradermal or intravenous injection of melanoma cells.
|
25745999 |
2015 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lentiviral miR30-based RNA interference against heparanase suppresses melanoma metastasis with lower liver and lung toxicity.
|
23847439 |
2013 |
melanoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
Heparanase DNA vaccine delivered by electroporation induces humoral immunity and cytoimmunity in animal models.
|
22240343 |
2012 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
An artificial miRNA against HPSE suppresses melanoma invasion properties, correlating with a down-regulation of chemokines and MAPK phosphorylation.
|
22719918 |
2012 |
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, VEGF likely has a potential function as a regulator of heparanase expression in melanoma.
|
21624769 |
2011 |
melanoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Atypical melanocytes and melanoma cells expressed heparanase, VEGF and VEGFR-2.
|
18288398 |
2008 |
melanoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Heparanase mechanisms of melanoma metastasis to the brain: Development and use of a brain slice model.
|
16288472 |
2006 |
melanoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Elevated HPSE expression contributes to melanoma progression; however, further augmentation of HPSE presence can inhibit tumorigenicity.
|
16867222 |
2006 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest that HPSE-1 not only contributes to the invasive phenotype of melanoma cells, but also that the Ad-AS/hep-mediated inhibition of its enzymatic activity can be efficacious in the prevention and treatment of melanoma metastasis.
|
15799825 |
2005 |
melanoma
|
0.400 |
Biomarker
|
disease |
LHGDN |
Our results provide evidence demonstrating that HPSE-1 likely plays important roles in regulating the in vivo growth and progression of melanoma.
|
15645118 |
2005 |
melanoma
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Restoration of HPSE-1 expression and functionality following Ad-S/hep infection of KCREB-transfected 70W cells recovered melanoma cell invasiveness.
|
15368349 |
2004 |
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Restoration of HPSE-1 expression and functionality following Ad-S/hep infection of KCREB-transfected 70W cells recovered melanoma cell invasiveness.
|
15368349 |
2004 |
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The heparanase mRNA and protein are preferentially expressed in metastatic cell lines and in specimens of human melanomas and carcinomas.
|
10909416 |
2000 |
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low metastatic murine T-lymphoma and melanoma cells transfected with the heparanase cDNA acquired a highly metastatic phenotype in vivo, reflected by a massive liver and lung colonization.
|
10395325 |
1999 |