Disease: Multiple Myeloma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 AlteredExpression disease BEFREE PRL-3 is overexpressed in a subset of MM patients and may cooperate with STAT3 to promote survival of MM cells. 31130718 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 Biomarker disease BEFREE Abrogation of PRL-3 reduced myeloma cell survival, clonogenicity, and tumorigenesis, and detailed mechanistic studies revealed "deactivation" of effector proteins such as Akt, Erk1/2, Src, STAT1, and STAT3. 31337650 2019
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 Biomarker disease BEFREE PRL-3 has also been identified as a marker gene for a subgroup of patients with MM. 27036022 2016
CUI: C0026764
Disease: Multiple Myeloma
Multiple Myeloma 		0.040 AlteredExpression disease BEFREE Silencing of the PRL-3 gene by siRNA reduced cell migration in the MM cell line INA-6, but had no detectable effect on proliferation and cell-cycle phase distribution of the cells. 17934070 2008