PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Primary biliary cirrhosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.220 AlteredExpression disease BEFREE The nuclear expression of PGC-1α, Bcl-3 and ERRα was exclusively observed in CNSDC of PBC. 24293610 2014
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.220 GeneticVariation disease BEFREE These results suggested that the genetic variants of CYP7A1 and its transcriptional activators (HNF4A and PPARGC1A) may activate bile acid synthesis, resulting in the accumulation of bile acids in hepatocytes and eventually leading to the predisposition to PBC progression. 23354620 2013
CUI: C0008312
Disease: Primary biliary cirrhosis
Primary biliary cirrhosis 		0.220 Biomarker disease RGD