Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our data demonstrate that sphingolipid balance, and increased AMPK, SIRT1, PGC-1α, and CS protein expression are part of the mechanism that contributes to the remission of diabetes after RYGB surgery.
|
30809769 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The TM ameliorated the pathological damages, reduced myocardial oxidative stress damages, restrained apoptosis, and upregulated the expressions of ATF6, RACK1, PERK, GRP78 and PGC-1α compared with those of the ischemia/reperfusion (I/R) group in DM.
|
31545290 |
2019 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We verified the function and mechanism of CHOP and provide evidence that CHOP and PGC-1α may serve as potential candidates for the clinical treatment of DM.
|
30848505 |
2019 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This review summarizes a growing body of literature surrounding possible links between the PGC-1α Gly482Ser single nucleotide polymorphism and diabetes, with focus on key clinical findings, affected metabolic systems, potential molecular mechanisms, and the influence of geographical or ethnic background on associated risk.
|
29186342 |
2018 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
However, despite decreased PGC-1α, concomitant changes in TFAM and mtDNA content by diabetes were not observed in females.
|
28864016 |
2017 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The molecular mechanisms underlying the regulation of PGC-1α in placenta in the context of diabetes remain unclear.
|
28433632 |
2017 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Yet, it may not represent a useful target for therapeutic strategies against diabetes as it exerts both beneficial and deleterious actions on glucose homoeostasis, and because PGC-1α modulation is involved in neurodegenerative diseases.
|
25753246 |
2015 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Inhibition of PGC-1α or control of hyperglycemia may be beneficial in improving the efficacy of chemotherapy in MM patients with diabetes.
|
25695395 |
2015 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The mitochondrial protective gene PGC-1α is also closely related to diabetes, and UCP2 is related to anti-mitochondrial oxidative stress, but the mechanism of action of these genes is unclear.
|
26315270 |
2015 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Together, these results provide new insights into potential cooperative roles of PINK1 and PGC-1α in mitochondrial fatty acid oxidation, suggesting possible regulatory roles for mitochondrial function in the pathogenesis of AD and diabetes.
|
25260493 |
2014 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
This selective reduction in PGC-1α was associated with the presence of diabetes mellitus (P<0.05).
|
24463787 |
2014 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, we examined the mechanism responsible for decreased PGC-1alpha expression using a rodent streptozotocin (STZ) model of chronic diabetes and atrophy.
|
20359506 |
2010 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Acute exercise caused a fourfold increase in PGC-1alpha expression in muscle from control subjects but not in subjects with diabetes.
|
20032281 |
2010 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction.
|
19077249 |
2008 |
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We review the evidence for relationships between thyroid hormone action and diabetes risk, and discuss potential mechanisms linking intracellular thyroid hormone availability, thyroid receptor action, and the transcriptional coactivator PGC1 in regulating oxidative metabolism.
|
18279023 |
2008 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interestingly, five positional candidate genes for diabetes and related complications are located in our linkage region (the pituitary adenylate cyclase activating polypeptide (PACAP in 18p11); the peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1 in 4p15); PTEN, PPP1R5, and IDE located in 10q23.
|
17548123 |
2007 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.
|
17031255 |
2006 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration.
|
17018837 |
2006 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure.
|
16511594 |
2006 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that PPARGC1A is likely to contribute to the risk of diabetes in offspring of patients with type 2 diabetes.
|
15912394 |
2005 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In population studies a Gly482Ser substitution in PGC-1alpha has been reported to be associated with increased risk of type diabetes 2 and insulin resistance.
|
16403952 |
2005 |
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To address this question we studied expression of these genes in muscle biopsies obtained from young and elderly dizygotic and monozygotic twins without known diabetes before and after insulin stimulation and related the expression to a Gly482Ser variant in the PGC-1alpha gene.
|
15546003 |
2004 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1.
|
12832613 |
2003 |
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, PGC-1alpha is a key activator of CYP7A1 and bile acid biosynthesis and is likely responsible for the fasting and diabetes dependent induction of CYP7A1.
|
14522988 |
2003 |
Diabetes Mellitus
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.
|
12808457 |
2003 |