|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Combined L-LAME and HF diet-induced hypertension is related to increased oxidative stress, inhibiting AMP-activated protein kinase (AMPK)/ peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) pathway and altered gut microbiota compositions.
|
31108332 |
2019 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased adipose cell size, hepatic fat deposition, malondialdehyde (MDA) content and NEFA level, down-regulation of IRS1, IRS2, PI3K, Akt, p-Akt, Glut2 and PGC1ɑ expression concomitant with up-regulation of mTOR, GSK3β, TNF-ɑ, FOXO1, p-mTOR and p-p70S6K expression in the liver tissue, as well as hypertension and left ventricular diastolic dysfunction were observed in HFC-fed minipigs.
|
30686655 |
2019 |
|
Hypertensive disease
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Resveratrol mediated its protective effect on HF/HF-induced hypertension in the kidneys of male offspring by diminishing oxidative stress; reducing renal asymmetric dimethylarginine levels; mediating the renin-angiotensin system (RAS) in favor of vasodilatation; restoring nutrient-sensing pathways via increased levels of silent information regulator transcript 1 (SIRT1), AMP-activated protein kinase 2α and peroxisome proliferator-activated receptor gamma coactivator 1-α; and inducing autophagy.
|
28825991 |
2017 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Sustained elevation of NF-κB activity sensitizes offspring of maternal inflammation to hypertension via impairing PGC-1α recovery.
|
27616627 |
2016 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Deletion of endothelial PGC-1α sensitized mice to endothelial dysfunction and hypertension in response to ATII, whereas PGC-1α EC TG mice were protected.
|
27910955 |
2016 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The influence of ethnicity in the association of WC, WHR, hypertension and PGC-1α (Gly482Ser), UCP2 -866 G/A and SIRT1 -1400 T/C polymorphisms with T2D in the population of Punjab.
|
25773007 |
2015 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Impact of the PPARGC1A Gly482Ser polymorphism on left ventricular structural and functional abnormalities in patients with hypertension.
|
24718382 |
2014 |
|
Hypertensive disease
|
0.100 |
Biomarker
|
group |
BEFREE |
Markers at the peroxisome proliferative activated receptor gamma coactivator 1α (PPARGC1A) and bradykinin β2 receptor (BDKRB2) genes were nominally associated with greater risk of hypertension, although one marker each at the BDKRB2 and endothelial nitric oxide synthase-3 (NOS3) genes were nominally associated with lower risk.
|
20944660 |
2011 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We concluded that PGC-1α Gly482Ser polymorphism is associated with hypertension in Mongolians in Inner Mongolia.
|
22194199 |
2011 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The Gly482Ser polymorphism in peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A) has been demonstrated to be associated with diabetes, obesity and hypertension, all of which are important risk factors for left ventricular diastolic dysfunction.
|
19077249 |
2008 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension.
|
18614852 |
2008 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
No association was found between PGC-1alpha polymorphism and hypertension with or without LVH.
|
17579564 |
2007 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
In this study, we found that G482S and +2962A/G polymorphisms of PGC-1alpha gene were only significantly associated with severe hypertension defined by occasional clinic blood pressure measurements.
|
17971240 |
2007 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we found that G482S and +2962A/G polymorphisms of PGC-1alpha gene were only significantly associated with severe hypertension defined by occasional clinic blood pressure measurements.
|
17971240 |
2007 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
In conclusion, the Gly482 Ser variant of the PGC-1alpha gene may be an independent genetic risk factor for young-onset hypertension.
|
16216916 |
2005 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recent studies suggested linkage between the chromosomal region of PGC-1alpha and fasting serum insulin levels, and associates a Gly482Ser polymorphism of the gene with type 2 diabetes and hypertension.
|
15649578 |
2005 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites.
|
15738346 |
2005 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the Gly482 Ser variant of the PGC-1alpha gene may be an independent genetic risk factor for young-onset hypertension.
|
16216916 |
2005 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
In conclusion, the Ser allele of PGC-1alpha Gly482Ser confers a significantly reduced risk of hypertension in whites.
|
15738346 |
2005 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.
|
15824463 |
2004 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have observed a sex-specific association between the PPARGC-1 gene Gly482Ser polymorphism and arterial hypertension in type 2 diabetic men.
|
15599700 |
2004 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Here, we assessed the association between the Gly482Ser variant of PPARGC1 and the arterial hypertension frequently found in subjects with type 2 diabetes.
|
15599700 |
2004 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results suggest, but do not prove, that PPARGC1 participates in blood pressure control, and sequence substitutions at its gene locus confer an increased risk of hypertension to a substantial proportion of men.
|
12574109 |
2003 |
|
Hypertensive disease
|
0.100 |
GeneticVariation
|
group |
LHGDN |
These results suggest, but do not prove, that PPARGC1 participates in blood pressure control, and sequence substitutions at its gene locus confer an increased risk of hypertension to a substantial proportion of men.
|
12574109 |
2003 |