PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Osteoporosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.030 Biomarker disease BEFREE Quantitative reverse transcription-polymerase chain reaction illustrated that miR-23a-3p expression was significantly increased, while PGC-1α/WNT/β-catenin signaling related proteins were significantly inhibited in tibia bone tissues of osteoporosis rat compared with normal control rat. 31691358 2019
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.030 Biomarker disease BEFREE (2018) show that PGC-1α regulates marrow mesenchymal stromal cell lineage allocation in vivo, inhibiting marrow adipogenesis and associated bone loss in the aging skeleton and following ovariectomy-induced osteoporosis. 30075123 2018
CUI: C0029456
Disease: Osteoporosis
Osteoporosis 		0.030 Biomarker disease BEFREE Our results suggest that PGC-1α is a potentially important therapeutic target in the treatment of osteoporosis and skeletal aging. 30017591 2018