PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Renal fibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.240 AlteredExpression disease BEFREE Inhibition of Smad3 and/or JNK signaling activities prevented down-regulation of PGC-1α in tubular epithelial cells and up-regulation of PGC-1α in myofibroblasts during FA-induced renal fibrosis and inflammation. 31447676 2019
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.240 Biomarker disease BEFREE However, whether PGC-1α is involved in the pathogenesis of renal fibrosis is unknown. 29913155 2018
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.240 Biomarker disease BEFREE PGC-1α ameliorates kidney fibrosis in mice with diabetic kidney disease through an antioxidative mechanism. 29344670 2018
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.240 AlteredExpression disease BEFREE The antifibrotic role of rolipram in renal fibrosis relies on C/EBP-β and PGC-1α expression in tubular epithelial cells. 29216750 2018
CUI: C0151650
Disease: Renal fibrosis
Renal fibrosis 		0.240 Biomarker disease RGD In summary, these data suggest that IHG-1 increases mitochondrial biogenesis by promoting PGC-1α-dependent processes, potentially contributing to the pathogenesis of renal fibrosis. 21784897 2011