PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 GeneticVariation disease BEFREE Meta-analysis demonstrates Gly482Ser variant of PPARGC1A is associated with components of metabolic syndrome within Asian populations. 31678594 2020
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 Biomarker disease BEFREE Enterococcus faecalis sir2-like gene enhances aerobic metabolism of themselves and mitochondrial respiration of mammal cells to bring about improving metabolic syndrome through the PGC-1α pathway. 30512225 2019
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 AlteredExpression disease BEFREE In our study, we hypothesized that an EET-agonist (AUDA) would increase expression of PGC 1α and improve mitochondrial and endothelial functions, resulting in improved heart function in a rat model of MS. To investigate this, rats were randomly divided into four groups: 1) Control; 2) MS + ABCT; 3) MS + AUDA; and 4) MS + AUDA + SnMP. 30342783 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 Biomarker disease BEFREE This view is consistent with known physiological role of ACOX1 in yielding precursors of specialized proresolving mediators (SPM) and with characteristics of aging and related disorders including reduced PGC1-<i>α</i> function and improvement by strategies rising ACOX1 (via hormonal gut FGF19 and nordihydroguaiaretic acid in metabolic syndrome and diabetes conditions) and SPM (neurodegenerative disorders, atherosclerosis, and stroke). 29765501 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 GeneticVariation disease BEFREE Relationship of PGC-1α gene polymorphism with insulin resistance syndrome in Korean children. 23449621 2015
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 AlteredExpression disease BEFREE Hence, we explored a strategy to target PGC-1α expression to treat metabolic syndromes. 23250358 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 Biomarker disease RGD Skeletal muscle mitochondrial and metabolic responses to a high-fat diet in female rats bred for high and low aerobic capacity. 20383225 2010
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 GeneticVariation disease BEFREE This study aimed to investigate whether genetic variations in human PPARGC1 gene are associated with metabolic syndrome-related phenotypes and T2D among obese subjects. 16122961 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 GeneticVariation disease BEFREE In conclusion, the Gly482Ser polymorphism of the PGC-1alpha gene is not associated with the metabolic syndrome, related quantitative traits or cardiac hypertrophy among Danish Caucasian subjects. 15649578 2005
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.290 GeneticVariation disease BEFREE Our objective was to search for differences in genotypes of peroxisome proliferator-activated receptor gamma (PPARgamma) (Pro12 Ala) and its coactivator PGC-1alpha (Gly482 Ser) in adolescents harboring features of metabolic syndrome. 16216916 2005