PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Mitochondrial Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751651
Disease: Mitochondrial Diseases
Mitochondrial Diseases 		0.040 AlteredExpression group BEFREE Minimal effects of <i>spargel</i> (PGC-1) overexpression in a <i>Drosophila</i> mitochondrial disease model. 31292108 2019
CUI: C0751651
Disease: Mitochondrial Diseases
Mitochondrial Diseases 		0.040 Biomarker group BEFREE Finally, very recent evidence of the alteration of the pathways governed by SIRT1 and PGC-1α in human mitochondrial diseases will be described and the possible role of their mitochondrial forms will be briefly discussed. 22834844 2013
CUI: C0751651
Disease: Mitochondrial Diseases
Mitochondrial Diseases 		0.040 AlteredExpression group BEFREE PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders. 19297390 2009
CUI: C0751651
Disease: Mitochondrial Diseases
Mitochondrial Diseases 		0.040 Biomarker group BEFREE Here, I review which mitochondrial processes are affected in known mitochondrial disorders and discuss why PGC-1alpha mediated mitochondrial biogenesis offers a promising venue for treatment of mitochondrial disorders. 19859975 2009