PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Liver regeneration disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.030 Biomarker phenotype BEFREE We demonstrated that the PGC-secretome does not only have higher antioxidant and anti-inflammatory properties, but also has the potential of significantly enhancing liver regeneration in both in vivo and in vitro models of liver injury. 31717375 2019
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.030 AlteredExpression phenotype BEFREE Post-treatment with the known MB inducer SRT1720 increased Pgc-1α expression and liver regeneration, resulting in protection against late liver injury after APAP overdose. 28827156 2017
CUI: C1318485
Disease: Liver regeneration disorder
Liver regeneration disorder 		0.030 AlteredExpression phenotype BEFREE An increased expression of genes associated with liver regeneration (STAT3, ALR) and energy metabolism (PGC-1α, COX, Nampt) was found in T2 (p < 0.05). 28941575 2017