PPARGC1A, PPARG coactivator 1 alpha, 10891

N. diseases: 350; N. variants: 42
Disease: Mammary Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 GeneticVariation group BEFREE PGC-1α deletion drastically delayed breast tumor onset in an orthotopic mouse model, highlighting a key role for PGC-1α in tumor initiation. 29930100 2018
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group LHGDN Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. 16704985 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 Biomarker group LHGDN These findings were corroborated by mRNA analysis which also demonstrated lower levels of both PGC-1 and PPARgamma in breast tumour tissue. 15254719 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.040 AlteredExpression group LHGDN Expression of peroxisome-proliferator activated receptor-gamma (PPARgamma) and the PPARgamma co-activator, PGC-1, in human breast cancer correlates with clinical outcomes. 12866036 2003