|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we present longitudinal three-dimensional intravital imaging of vascular and tumor microenvironment remodeling in spontaneous transgenic tumors (RIP1-Tag2 insulinomas) and orthotopically injected tumors (KPC adenocarcinomas).
|
31661557 |
2020 |
|
Arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibition of RIP1 reduced collagen antibody-induced arthritis, and prevented skin inflammation caused by mutation of Sharpin, or colitis caused by deletion of Nemo from intestinal epithelial cells.
|
31101885 |
2020 |
|
Liver Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on the results, it seems that IPS-1 and RIP1 can participate in the induction of low chronic inflammation, which is a main cause of liver cirrhosis and hepatocellular carcinoma.
|
31429854 |
2020 |
|
Parkinson Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulating the expression of RIP1, RIP3, or MLKL can significantly attenuate MPTP-induced PD.
|
31506635 |
2020 |
|
Secondary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Conversely, inhibition of RIP1 had no effect on tumor growth or survival in pancreatic tumor models driven by mutant Kras, nor did it reduce lung metastases in a B16 melanoma model.
|
31101885 |
2020 |
|
Hepatitis B, Chronic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this project, mRNA levels of IPS-1 and RIP1 were investigated in the peripheral blood immune cells of chronic hepatitis B (CHB) patients.
|
31429854 |
2020 |
|
Inflammatory disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Collectively, our data emphasize a role for the kinase activity of RIP1 in certain inflammatory disease models, but question its relevance to tumor progression and metastases.
|
31101885 |
2020 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Collectively, our data emphasize a role for the kinase activity of RIP1 in certain inflammatory disease models, but question its relevance to tumor progression and metastases.
|
31101885 |
2020 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The results indicated that the necroptosis-related proteins RIP1 and RIP3 significantly increased postoperation in the spinal cord in a neuropathic pain model and peaked 7 days postoperation, which was consistent with the time-dependent changes of hyperalgesia.
|
31156396 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The results indicated that the necroptosis-related proteins RIP1 and RIP3 significantly increased postoperation in the spinal cord in a neuropathic pain model and peaked 7 days postoperation, which was consistent with the time-dependent changes of hyperalgesia.
|
31156396 |
2019 |
|
Septicemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
NEW & NOTEWORTHY The present study demonstrated that a chemical inhibitor necrostatin-1 (Nec-1) or receptor-interacting protein kinase(RIP1) knock down targeted at necroptosis inhibition accelerated liver injury of following sepsis.
|
30735454 |
2019 |
|
Neuroendocrine Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
Alleles of Insm1 determine whether RIP1-Tag2 mice produce insulinomas or nonfunctioning pancreatic neuroendocrine tumors.
|
30796198 |
2019 |
|
Sepsis
|
0.010 |
Biomarker
|
disease |
BEFREE |
NEW & NOTEWORTHY The present study demonstrated that a chemical inhibitor necrostatin-1 (Nec-1) or receptor-interacting protein kinase(RIP1) knock down targeted at necroptosis inhibition accelerated liver injury of following sepsis.
|
30735454 |
2019 |
|
Antibiotic-associated diarrhea
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these results establish that high, but not low, CPE concentrations cause necroptosis and suggest that RIP1, RIP3, MLKL, or calpain inhibitors can be explored as potential therapeutics against CPE effects <i>in vivo</i><b>IMPORTANCE</b><i>C. perfringens</i> type F strains are a common cause of food poisoning and antibiotic-associated diarrhea.
|
31848291 |
2019 |
|
Papillary Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Drug resistance to multiple therapies in pRCC occurs via genetic alteration (such as mutations resulting in abnormal receptor tyrosine kinase activation or RALBP1 inhibition), dysregulation of signalling pathways (such as GSK3β-EIF4EBP1, PI3K-AKT and the MAPK or interleukin signalling pathways), deregulation of cellular processes (such as resistance to apoptosis or epithelial-to-mesenchymal transition) and interactions between the cell and its environment (for example, through activation of matrix metalloproteinases).
|
31602010 |
2019 |
|
Pancreatic Endocrine Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In particular, anti-VEGF/R therapies produce hypoxia-induced invasion and metastasis in a spontaneous mouse model of pancreatic neuroendocrine cancer (PanNET), RIP1-Tag2.
|
31239269 |
2019 |
|
Tumor Angiogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
RLIP76 plays an essential role in tumor angiogenesis through the regulation of pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1).
|
30999946 |
2019 |
|
Patent ductus arteriosus
|
0.010 |
Biomarker
|
disease |
BEFREE |
RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human PDA.
|
30423296 |
2018 |
|
Lymphatic Metastasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
RIP1 regulates TNF-α-mediated lymphangiogenesis and lymphatic metastasis in gallbladder cancer by modulating the NF-κB-VEGF-C pathway.
|
29844685 |
2018 |
|
Acute myocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the roles of RIP1/RIP3 mediated cardiomyocyte necroptosis in CVB3-induced acute myocarditis.
|
28887702 |
2018 |
|
Impaired cognition
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibiting RIP1 Improves Chronic Stress-Induced Cognitive Impairments in D-Galactose-Induced Aging Mice.
|
30356849 |
2018 |
|
Tumor Immunity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human PDA.
|
30423296 |
2018 |
|
PATENT DUCTUS ARTERIOSUS 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human PDA.
|
30423296 |
2018 |
|
Acute pancreatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Deletion of XIAP resulted in the reduction of amylase activity, decrease of NF-κB activation and less release of TNF-α and IL-6, together with increased caspases activities and RIP1 degradation, leading to enhanced apoptosis and reduced necrosis in pancreatic acinar cells and ameliorated the severity of acute pancreatitis.
|
28300832 |
2017 |
|
Congestive heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of RIP1 (receptor-interacting protein), pSer<sup>227</sup>-RIP3 and its total levels were observed in HF groups compared to controls.
|
28454582 |
2017 |