|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition to apoptosis, necroptosis also plays critical roles in pathological changes in mandibular cartilage after compressive mechanical force stimulation, implying RIP1, a master protein that mediates both necroptosis and apoptosis, as a potential therapeutic target in temporal mandibular osteoarthritis.
|
28396243 |
2017 |
|
Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Growth kinetics and vascular histopathology of several types of solid tumors was evaluated, namely Lewis Lung Carcinoma xenografts, chemically-induced skin papillomas and RIP1-Tag2 insulinomas.
|
28288569 |
2017 |
|
Ureteral obstruction
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The levels of RIP1/RIP3/MLKL protein and mRNA were increased in the obstructed kidneys 7 days after UUO; this was accompanied by changes in renal pathological lesions.
|
28723681 |
2017 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, RIP1 is a central signaling protein in regulation of apoptosis and necroptosis during NDV infection.
|
28591723 |
2017 |
|
Gastrointestinal tract vascular insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results showed that intestinal ischaemia caused RIP1-dependent epithelial necroptosis and villus destruction accompanied by a reduction in crypt proliferation.
|
27121603 |
2017 |
|
Chronic heart failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated expression of RIP1 (receptor-interacting protein), pSer<sup>227</sup>-RIP3 and its total levels were observed in HF groups compared to controls.
|
28454582 |
2017 |
|
Neuroblastoma recurrent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present review, we discuss the mechanisms and the role of RLIP76 in oxidative stress, drug-resistance and clathrin-dependent endocytosis (CDE), and analyze the molecular basis for the role of RLIP76 targeted approaches in the context principal drivers of NB pathogenesis, progression and drug-resistance.
|
28386633 |
2017 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
TNF Signaling through RIP1 Kinase Enhances SN38-Induced Death in Colon Adenocarcinoma.
|
28087739 |
2017 |
|
Vascular insufficiency of intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results showed that intestinal ischaemia caused RIP1-dependent epithelial necroptosis and villus destruction accompanied by a reduction in crypt proliferation.
|
27121603 |
2017 |
|
Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other important effectors of RalA pathway including RalA binding protein-1 (RalBP1) and protein phosphatase A (PP2A) down-stream of Ral and Aurora kinase A (AKA) as an upstream RalA activator were also investigated in MDB.
|
27566179 |
2016 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggested that miR-675-5p might play an oncogenic role in ESCC through RalBP1/RAC1/CDC42 signaling pathway by inhibiting REPS2 and might serve as a valuable prognostic biomarker and therapeutic target for ESCC patients.
|
27120794 |
2016 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of RALBP1 induced apoptosis of the ovarian cancer cells, and developed ovarian cancer.
|
27748916 |
2016 |
|
Malignant neoplasm of ovary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of RALBP1 induced apoptosis of the ovarian cancer cells, and developed ovarian cancer.
|
27748916 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of RALBP1 induced apoptosis of the ovarian cancer cells, and developed ovarian cancer.
|
27748916 |
2016 |
|
Meningioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry showed an increased RLIP76 immunostaining score in anaplastic and atypical meningiomas versus classical meningiomas.
|
25993541 |
2015 |
|
B-Cell Lymphomas
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Western blot analysis revealed that cells underexpressing RLIP76 exhibited decreased B-cell lymphoma-2(Bcl-2) expression but increased apoptosis effector caspase-3 expression.
|
25993541 |
2015 |
|
Malignant Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings demonstrate that high RLIP76 expression is associated with a poor outcome of meningioma and may provide a new gene therapy approach for patients with malignant meningiomas.
|
25993541 |
2015 |
|
Adult Meningioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression of RLIP76 in meningioma and correlated the RLIP76 expression to the patient outcome.
|
25993541 |
2015 |
|
Recurrent tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Univariate and Cox analysis indicated that RLIP76 was an independent prognostic factor for tumor recurrence.
|
25993541 |
2015 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, our results indicated that RLIP76 mRNA and protein were highly expressed in the breast cancer tissues while compared with adjacent normal mammary tissues and the correlation with RLIP76 protein expression was significantly associated with age (the non-ABC transporter, stage and the expression were significantly associated-T2 vs. T3-T4, p < 0.01), lymph node metastasis (N0-N1 vs. N2-N3, p < 0.01), and PR (positive vs. negative, p < 0.01) in breast cancer patients; furthermore, we also found that RLIP76 protein overexpression was an unfavorable prognostic factor in the patients suffered from breast cancer.
|
26125275 |
2015 |
|
Meningioma, benign, no ICD-O subtype
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we examined the expression of RLIP76 in meningioma and correlated the RLIP76 expression to the patient outcome.
|
25993541 |
2015 |
|
Angiogenic Switch
|
0.010 |
Biomarker
|
disease |
BEFREE |
The matrisome, comprising extracellular matrix (ECM) and ECM-associated molecules, is significantly enriched, which allowed us to define the AngioMatrix signature as the 110 matrisomal genes induced during the RIP1-Tag2 angiogenic switch.
|
25301723 |
2014 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
A 76-kDa Ral-interacting protein (RLIP76) has been implicated in the pathogenesis of cancer and diabetes.
|
23419874 |
2013 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
A 76-kDa Ral-interacting protein (RLIP76) has been implicated in the pathogenesis of cancer and diabetes.
|
23419874 |
2013 |
|
Hyperinsulinism
|
0.010 |
Biomarker
|
disease |
BEFREE |
RLIP76 homozygous knockout mice exhibit increased insulin sensitivity, hypoglycemia, and hypolipidemia, and resist cancer development.
|
23419874 |
2013 |