|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
<b>Methods:</b> The effects of DCZ0814 were evaluated in vitro using human MM cell lines (ARP1 and OCI-MY5) and in vivo in a murine xenograft MM model.
|
31213901 |
2019 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
In ARP-1 and MM.1S tumor-bearing mice, repeat STRO-001 dosing provided significant antitumor activity with eradication of malignant hCD138+ BM plasma cells and prolonged survival.
|
30701025 |
2018 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We applied ND and MM-MSCs 72h secretomes to MM cell lines (U266 and ARP-1) for 12-72h and then assayed the cells' (viability, cell count, cell death, proliferation, cell cycle, autophagy) and TI (factors: eIF4E, teIF4GI; regulators: mTOR, MNK1/2, 4EBP; targets: cyclin D1, NFκB, SMAD5, cMyc, HIF1α).
|
26976208 |
2016 |
|
Multiple Myeloma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Forced expression of bcl-2 in 8226 and ARP-1 multiple myeloma (MM) cell lines expressing relatively low levels of bcl-2, resulted in 1-2 log increase in resistance to dexamethasone (DEX)-induced apoptosis.
|
9454907 |
1998 |
|
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
High-yield, water-soluble, and purification-free MucoRice-ARP1 thus forms the basis for orally administered prophylaxis and therapy against rotavirus infections.
|
23925294 |
2013 |
|
Rotavirus Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Previously we have shown that a recombinant monovalent antibody fragment (referred to as Anti-Rotavirus Proteins or ARP1) derived from a heavy chain antibody of a llama immunised with rotavirus was able to neutralise rotavirus infection in a mouse model system.
|
22403728 |
2012 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Together with the fact that the proinflammatory cytokine tumor necrosis factor-α induces ectopic expression of APOBEC2 in hepatocytes, our findings indicate that aberrant APOBEC2 expression causes nucleotide alterations in the transcripts of the specific target gene and could be involved in the development of human hepatocellular carcinoma through hepatic inflammation.
|
21469143 |
2012 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1.
|
1321332 |
1992 |
|
Hepatitis B
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, the findings of the present study may provide insight into the mechanistic role of HBV infection in modulating the expression of miR‑122, which targets the 3'UTR of APOBEC2 mRNA, subsequently inducing liver carcinogenesis.
|
31485598 |
2019 |
|
leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The rabbit skin tumours induced via blood infection displayed decreased expression of SLN, TAC1, MYH8, PGAM2, and APOBEC2 and increased expression of SDRC7, KRT16, S100A9, IL36G, and FABP9, as seen in tumours induced by local infections.
|
31340720 |
2019 |
|
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
One reported mechanism underlying the development of liver cancer is the mutation of tumor suppressor genes induced by the overexpression of apolipoprotein B mRNA‑editing enzyme catalytic subunit 2 (APOBEC2) in hepatocytes.
|
31485598 |
2019 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of note, the expression profile of APOBEC2 in the Huh7 and HepG2 liver cancer cell lines opposed that of miR‑122; this miR is the most abundant miRNA in the liver and has been associated with hepatocarcinogenesis.
|
31485598 |
2019 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of note, the expression profile of APOBEC2 in the Huh7 and HepG2 liver cancer cell lines opposed that of miR‑122; this miR is the most abundant miRNA in the liver and has been associated with hepatocarcinogenesis.
|
31485598 |
2019 |
|
Malignant neoplasm of liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of note, the expression profile of APOBEC2 in the Huh7 and HepG2 liver cancer cell lines opposed that of miR‑122; this miR is the most abundant miRNA in the liver and has been associated with hepatocarcinogenesis.
|
31485598 |
2019 |
|
Hepatocarcinogenesis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, the findings of the present study may provide insight into the mechanistic role of HBV infection in modulating the expression of miR‑122, which targets the 3'UTR of APOBEC2 mRNA, subsequently inducing liver carcinogenesis.
|
31485598 |
2019 |
|
Myopathy
|
0.010 |
Biomarker
|
group |
BEFREE |
We conclude that Apobec2 deficiency causes mitochondrial defects that increase muscle mitophagy, leading to myopathy and atrophy.
|
29127187 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.010 |
Biomarker
|
group |
BEFREE |
Orally administered MucoRice-ARP1 markedly decreased the viral load in immunocompetent and immunodeficient mice.
|
23925294 |
2013 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, constitutive APOBEC2 expression caused lung tumors in 7 of 20 transgenic mice analyzed.
|
21469143 |
2012 |
|
Carcinogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Excessive activity of apolipoprotein B mRNA editing enzyme catalytic polypeptide 2 (APOBEC2) contributes to liver and lung tumorigenesis.
|
21469143 |
2012 |
|
IGA Glomerulonephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The APOBEC2 was confirmed to be elevated in the tonsils with IgAN patients, and the gene expression level was negatively related with serum igg level in overall patients.
|
20138841 |
2010 |
|
Spinocerebellar Ataxia Type 5
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Beta-III spectrin mutation L253P associated with spinocerebellar ataxia type 5 interferes with binding to Arp1 and protein trafficking from the Golgi.
|
20603325 |
2010 |
|
Acute leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene.
|
9539779 |
1998 |
|
Choriocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Co-transfection of an ARP-1 expression vector into BeWo choriocarcinoma cells, along with an expression vector containing 1.2 kb of the hPL promoter coupled to a CAT reporter gene, resulted in a dose-dependent inhibition of basal CAT activity.
|
8782080 |
1996 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Transient transfection assays showed that site A is necessary and sufficient for RXR alpha-mediated transactivation of the apoAI gene basal promoter in human hepatoma HepG2 cells in the presence of RA and that this transactivation is abolished by increasing amounts of cotransfected ARP-1.
|
1321332 |
1992 |