|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thirteen pts had Acute Promyelocytic Leukemia (APL) with rearrangements of the RAR-a and PML genes, 8 BCR rearranged (BCR+)/Ph+ Chronic Myeloid Leukemia (CML) and 3 BCR+/Ph+ Acute Lymphoid Leukemia (ALL).
|
8152281 |
1994 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that in APL, the t(15;17) translocation generates an RAR mutant that could contribute to leukemogenesis through interference with promyelocytic differentiation.
|
1652369 |
1991 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The NPM-RAR fusion protein associated with the t(5;17) variant of APL does not interact with PML.
|
16504291 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Acute Promyelocytic Leukemia (APL) with break points in the (RAR) gene and the zyl gene also produces a fusion transcript.
|
8251913 |
1993 |
|
Acute Promyelocytic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the E-domain of RAR portion of the PML/RAR chimeric gene may confer clinical resistance to all-trans retinoic acid in acute promyelocytic leukemia.
|
9657734 |
1998 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A growing body of evidence supports the hypotheses that the retinoic acid receptor beta2 (RAR-beta2) gene is a tumor suppressor gene and that the chemopreventive effects of retinoids are due to induction of RAR-beta2.
|
10814678 |
2000 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hypermethylation of the CDH1 was significantly associated with primary breast tumors demonstrating lymphovascular invasion (P = 0.008), infiltrating ductal histology (P = 0.03), and negative for the estrogen receptor (P = 0.005), whereas RASSF1A and RAR-beta2 gene hypermethylation were significantly more common in estrogen receptor-positive (P < 0.001) and human epidermal growth factor receptor 2-positive (P < 0.001) tumors, respectively.
|
15788661 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The RAR-beta2 gene from non-neoplastic cervical tissues was mostly unmethylated and expressed, but methylated alleles of the gene were found in three samples of the morphologically normal tissues adjacent to the tumors.
|
11945179 |
2002 |
|
Carcinogenesis
|
0.070 |
GeneticVariation
|
phenotype |
BEFREE |
Methylation of the RAR-beta2 gene may be an initial step in breast carcinogenesis; treatment of cancer patients with demethylating agents followed by retinoic acid may offer a new therapeutic modality.
|
10814678 |
2000 |
|
Neoplasm Metastasis
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
In multivariate analysis, hypermethylation of GSTP1 and/or RAR-beta2 was significantly associated with patients having macroscopic SLN metastasis compared with those with microscopic or no sentinel node metastasis (odds ratio, 4.59; 95% confidence interval, 2.02-10.4; P < 0.001).
|
15788661 |
2005 |
|
Tumor Cell Invasion
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Hypermethylation of the CDH1 was significantly associated with primary breast tumors demonstrating lymphovascular invasion (P = 0.008), infiltrating ductal histology (P = 0.03), and negative for the estrogen receptor (P = 0.005), whereas RASSF1A and RAR-beta2 gene hypermethylation were significantly more common in estrogen receptor-positive (P < 0.001) and human epidermal growth factor receptor 2-positive (P < 0.001) tumors, respectively.
|
15788661 |
2005 |
|
Colorectal Carcinoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The rest changed greatly in the methylation pattern in colorectal cancer (CRC): cyclin A1 (cyclin a1) (100%, 65/65), caudal type homeobox transcription factor 1 (CDX1) (100%, 65/65), RAR- (85%, 55/65), myogenic factor 3 (MYOD1) (69%, 45/65), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (p15(INK4b)) (68%, 44/65), prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (COX2) (72%, 47/65), cadherin 13, H-cadherin (heart) (CDH13) (65%, 42/65), CAAX box 1 (CXX1) (58%, 38/65), tumor protein p73 (p73) (63%, 41/65) and Wilms tumor 1 (WT1) (58%, 38/65).
|
15526363 |
2004 |
|
Leukemogenesis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These observations suggest that in APL, the t(15;17) translocation generates an RAR mutant that could contribute to leukemogenesis through interference with promyelocytic differentiation.
|
1652369 |
1991 |
|
Carcinoma of bladder
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that methylation of APC, RARβ and Survivin gene promoters is a common finding in patients with bladder carcinoma.
|
22992440 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Autistic Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Bipolar Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Borderline Personality Disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Bronchopulmonary Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
To test the hypothesis that genetic variants of the retinoid receptor genes may predispose to schizophrenia and other psychiatric diseases, the six RAR and RXR genes and a heterodimer partner, the NURR1 gene, were scanned in 100 schizophrenia patients, along with pilot studies in 20-24 patients with bipolar disorder (BPD), attention-deficit hyperactivity disorder (ADHD), autism, or alcoholism.
|
15635645 |
2005 |
|
Hemorrhoids
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
All consecutive patients with symptomatic haemorrhoids who were treated with the HAL-RAR procedure between February 2008 and February 2014 in a single institution were included in the study.
|
31264350 |
2019 |
|
Myeloid Leukemia, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thirteen pts had Acute Promyelocytic Leukemia (APL) with rearrangements of the RAR-a and PML genes, 8 BCR rearranged (BCR+)/Ph+ Chronic Myeloid Leukemia (CML) and 3 BCR+/Ph+ Acute Lymphoid Leukemia (ALL).
|
8152281 |
1994 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The NPM sequences contained in the shorter NPM-RAR cDNA are identical to the NPM sequences contained in the NPM-ALK fusion gene expressed in t(2;5) lymphomas.
|
8562957 |
1996 |
|
Meningomyelocele
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
RAR genes were associated with risk for MM.
|
21254357 |
2011 |
|
Nephroblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The rest changed greatly in the methylation pattern in colorectal cancer (CRC): cyclin A1 (cyclin a1) (100%, 65/65), caudal type homeobox transcription factor 1 (CDX1) (100%, 65/65), RAR- (85%, 55/65), myogenic factor 3 (MYOD1) (69%, 45/65), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (p15(INK4b)) (68%, 44/65), prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (COX2) (72%, 47/65), cadherin 13, H-cadherin (heart) (CDH13) (65%, 42/65), CAAX box 1 (CXX1) (58%, 38/65), tumor protein p73 (p73) (63%, 41/65) and Wilms tumor 1 (WT1) (58%, 38/65).
|
15526363 |
2004 |
|
Psoriasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide mapping of epidermal 5-hmC in murine psoriasis revealed loci-specific loss of 5-hmC in genes regulating stem cell homeostasis, including MBD1, RTN1, STRN4, PRKD2, AKT1, MAPKAP2, as well as those associated with RAR and Wnt/β-catenin signaling pathways.
|
31837302 |
2019 |