|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In both pre- and post-conditioning where the priming dose was 0.1 Gy and the challenge dose was 4 Gy, RAR developed in T98G but not in HaCaT cells.
|
30496014 |
2019 |
|
Hemorrhoids
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
All consecutive patients with symptomatic haemorrhoids who were treated with the HAL-RAR procedure between February 2008 and February 2014 in a single institution were included in the study.
|
31264350 |
2019 |
|
Hypothyroidism
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarly, expression of TRα-1, TRβ-1, TSHR, ERK1/2 and RAR proteins and mRNA in the uterus of non-treated hypothyroid rats also decreased (P < 0.05 when compared to euthyroid and thyroxine-treated hypothyroid rats).
|
30761678 |
2019 |
|
Psoriasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide mapping of epidermal 5-hmC in murine psoriasis revealed loci-specific loss of 5-hmC in genes regulating stem cell homeostasis, including MBD1, RTN1, STRN4, PRKD2, AKT1, MAPKAP2, as well as those associated with RAR and Wnt/β-catenin signaling pathways.
|
31837302 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In both pre- and post-conditioning where the priming dose was 0.1 Gy and the challenge dose was 4 Gy, RAR developed in T98G but not in HaCaT cells.
|
30496014 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In both pre- and post-conditioning where the priming dose was 0.1 Gy and the challenge dose was 4 Gy, RAR developed in T98G but not in HaCaT cells.
|
30496014 |
2019 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
In both pre- and post-conditioning where the priming dose was 0.1 Gy and the challenge dose was 4 Gy, RAR developed in T98G but not in HaCaT cells.
|
30496014 |
2019 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These RAR characteristics correlated with greater fatigue (Spearman r = 0.36) but not depression symptom severity.
|
30024782 |
2018 |
|
Refractory anemias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, LPS-induced autophagy further reduced retinoic acid (RA) signaling, as demonstrated by a decrease in the intracellular RA level and Rar target genes, resulting in the downregulation of Bambi and promoting the sensitization of the HSC's fibrosis response to TGFB.
|
29160747 |
2017 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Additionally, LPS-induced autophagy further reduced retinoic acid (RA) signaling, as demonstrated by a decrease in the intracellular RA level and Rar target genes, resulting in the downregulation of Bambi and promoting the sensitization of the HSC's fibrosis response to TGFB.
|
29160747 |
2017 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, Foxp3 protein levels increased, while those of RAR‑related orphan receptor γ (RORγt) decreased after hPMSCs transplantation compared with the asthma group.
|
28944907 |
2017 |
|
Mental Depression
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Depression is associated with disturbances to sleep and the 24-h sleep-wake pattern (known as the rest-activity rhythm: RAR).
|
28488270 |
2017 |
|
Depressive disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Depression is associated with disturbances to sleep and the 24-h sleep-wake pattern (known as the rest-activity rhythm: RAR).
|
28488270 |
2017 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this report, we studied a novel function of RAR-related orphan receptor gamma (ROR-γ) in hepatocyte EMT during liver fibrosis.
|
27791279 |
2017 |
|
Depressed mood
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Depression is associated with disturbances to sleep and the 24-h sleep-wake pattern (known as the rest-activity rhythm: RAR).
|
28488270 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because 9cRA and 13-cis-retinoic acid, which is retinoic acid receptor-selective, prevent prostate carcinogenesis in rats, and 13-cis-retinoic acid also inhibits growth of human prostate cancer cells, the RAR is a potential molecular target for prostate cancer prevention and therapy.
|
26886237 |
2017 |
|
Congenital absence of kidney
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic investigations have identified several gene variants that cause RA, including <i>EYA1</i>, <i>LHX1</i>, and <i>WT1</i> However, whereas compound null mutations of genes encoding α and γ retinoic acid receptors (RARs) cause RA in mice, to date there have been no reports of variants in RAR genes causing RA in humans.
|
28739660 |
2017 |
|
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because 9cRA and 13-cis-retinoic acid, which is retinoic acid receptor-selective, prevent prostate carcinogenesis in rats, and 13-cis-retinoic acid also inhibits growth of human prostate cancer cells, the RAR is a potential molecular target for prostate cancer prevention and therapy.
|
26886237 |
2017 |
|
Congenital absence of kidneys syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic investigations have identified several gene variants that cause RA, including <i>EYA1</i>, <i>LHX1</i>, and <i>WT1</i> However, whereas compound null mutations of genes encoding α and γ retinoic acid receptors (RARs) cause RA in mice, to date there have been no reports of variants in RAR genes causing RA in humans.
|
28739660 |
2017 |
|
RENAL ADYSPLASIA
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic investigations have identified several gene variants that cause RA, including <i>EYA1</i>, <i>LHX1</i>, and <i>WT1</i> However, whereas compound null mutations of genes encoding α and γ retinoic acid receptors (RARs) cause RA in mice, to date there have been no reports of variants in RAR genes causing RA in humans.
|
28739660 |
2017 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Rab40b might be a novel prognostic marker and a candidate biological therapeutic target for GC.
|
25790780 |
2015 |
|
Lymphoma, T-Cell, Cutaneous
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The integrin-dependent adhesion changes in CTCL cells occurred through synergistic activation of RAR and RXR nuclear receptors.
|
25826424 |
2015 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings indicate that Rab40b might be a novel prognostic marker and a candidate biological therapeutic target for GC.
|
25790780 |
2015 |
|
MYELODYSPLASTIC SYNDROME
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Multivariate Cox regression analysis identified 7 factors that independently predicted short survival in t-MDS: age ≥ 65 years (hazard ratio [HR], 1.63), Eastern Cooperative Oncology Group performance status 2-4 (HR, 1.86), poor cytogenetics (-7 and/or complex; HR, 2.47), World Health Organization MDS subtype (RARs or RAEB-1/2; HR, 1.92), hemoglobin (< 11 g/dL; HR, 2.24), platelets (< 50 × 10(9)/dL; HR, 2.01), and transfusion dependency (HR, 1.59).
|
24875590 |
2014 |
|
Hepatitis C
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Here, we showed that HCV Core induced promoter hypermethylation of RAR-β2 to inhibit its expression via up-regulation of DNA methyltransferases 1 and 3b.
|
23474497 |
2013 |