|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dengue-1 envelope protein domain III produced in Pichia pastoris: potential use for serological diagnosis.
|
23993978 |
2013 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study was aimed at evaluating the genetic stability of a live attenuated West Nile (WN) virus vaccine candidate that was generated by replacing the pre-membrane and envelope protein genes of dengue 4 virus with those from WN.
|
21360544 |
2011 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
A star-shaped DNA architecture, carrying five molecular beacon-like motifs, was constructed to display ten dengue envelope protein domain III (ED3)-targeting aptamers into a two-dimensional pattern precisely matching the spatial arrangement of ED3 clusters on the dengue (DENV) viral surface.
|
31767992 |
2020 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The envelope protein (E) of dengue virus binds to receptors present on the host cells through its domain III that has been primarily recognized to bind cell receptors.
|
24324976 |
2013 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of dengue complex-specific neutralizing epitopes on the envelope protein domain III of dengue 2 virus.
|
19101005 |
2009 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, two highly conserved regions of dengue envelope protein were identified and an scFv was constructed against it.
|
30629625 |
2019 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Zika (ZIKV) and dengue (DENV) virus infections elicit a robust but cross-reactive antibody response against the viral envelope protein, while antibody responses against non-structural proteins (NS) are more virus specific.
|
30902827 |
2019 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present work, we have targeted the domain I/III hinge region using four known ligands used for the dengue envelope protein (serotype-2) and have intended to explore the specificity of one ligand R1 (5-(3-chlorophenyl)-N-(2-phenyl-2H-benzo[d][1,2,3]triazol-6-yl)furan-2-carboxamide) that succeeded the dengue inhibition by the molecular dynamics (MD) simulations in conjunction of the molecular docking and the binding free energy calculations.
|
28255859 |
2017 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The envelope protein (E protein) of dengue virus is responsible for a wide range of biological activities, including binding to host cell receptors and fusion to and entry into host cells.
|
29470620 |
2018 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Truncated recombinant dengue virus envelope protein subunits (80E) are efficiently expressed using the Drosophila Schneider-2 (S2) cell expression system.
|
20097152 |
2010 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The nucleic acid sequences of the pre-membrane/membrane and envelope protein genes of 23 geographically and temporally distinct dengue (DEN)-3 viruses were determined.
|
8113741 |
1994 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we focused on the Dengue viral envelope protein (E); computational analyses ranging from extensive Molecular Dynamics (MD) simulations and energy-decomposition-based prediction of potentially immunoreactive regions identified putative epitope sequences.
|
31003530 |
2019 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Total and Envelope Protein-Specific Antibody-Secreting Cell Response in Pediatric Dengue Is Highly Modulated by Age and Subsequent Infections.
|
27560782 |
2016 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation.
|
17459925 |
2007 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
It was previously reported that DIIIC-2 (a fusion protein composed of domain III of the envelope protein and the capsid protein from dengue 2 virus), as an aggregate antigen from a partially purified preparation, induced a functional protective immune response against dengue 2 virus in the mouse encephalitis model.
|
22983185 |
2013 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A single amino acid substitution in the envelope protein of chimeric yellow fever-dengue 1 vaccine virus reduces neurovirulence for suckling mice and viremia/viscerotropism for monkeys.
|
15331733 |
2004 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Despite antigenic similarities with dengue viruses, structural studies have suggested the extended CD-loop and hydrogen-bonding interaction network within the ZIKV envelope protein contribute to stability differences between the viral families.
|
28968838 |
2017 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, the consensus dengue virus envelope protein domain III fused to hydrophobin I of Trichoderma reesei was expressed in Pichia pastoris cultures and an in situ product removal by an ATPS using a non-ionic detergent, (Triton X-114) was performed.
|
30240632 |
2019 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recombinant fusion protein containing domain III of the dengue envelope protein fused to capsid protein from dengue 2 virus was immunogenic and conferred protection in mice against lethal challenge in previously report.
|
22554934 |
2012 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Small molecules that target the dengue virus envelope protein, E, on the surface of the virion could act analogously to antibodies by engaging E extracellularly to block infection; however, a shortage of target-based assays suitable for screening and medicinal chemistry studies has limited efforts in this area.
|
30027735 |
2018 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two studies in monkeys, combining recombinant protein PD5 (domain III of the envelope protein from dengue-2 virus, fused to the protein carrier P64k) and the infective dengue virus in the same immunization schedules were carried out.
|
19773190 |
2010 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The nucleotide sequences of a short fragment of the envelope protein gene encoding amino acids 25 to 89 of 27 dengue 3 viruses were determined by direct sequencing of PCR-amplified products, and the viruses were compared regarding their time of isolation and geographic distribution.
|
8277284 |
1993 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the genetic variability and to detect evolutionary changes and movement of dengue 2 (DEN-2) strains, nucleotide sequencing of the envelope protein gene and the nonstructural protein 1 gene junction was performed for 9 isolates from the 1996 Delhi epidemic and 1 isolate from the 1967 Delhi epidemic.
|
10479118 |
1999 |
|
Dengue Fever
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Although the envelope protein of DENV influenced EXO70 expression, the co-expression of pre-membrane and envelope proteins significantly increased the expression levels of EXO70 during DENV infection.
|
21034848 |
2011 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Atomic-level functional model of dengue virus Envelope protein infectivity.
|
24158478 |
2013 |