This force-sensitive mechanism may provide <i>S. aureus</i> with a means to finely tune its adhesive properties during the colonization of host surfaces, helping cells to attach firmly under high shear stress and to detach and spread under low shear stress.<b>IMPORTANCE</b><i>Staphylococcus aureus</i> colonizes the human skin and the nose and can cause various disorders, including superficial skin lesions and invasive infections.During nasal colonization, the <i>S. aureus</i> surface protein clumping factor B (ClfB) binds to the squamous epithelial cell envelope protein loricrin, but the molecular interactions involved are poorly understood.