Using GFP-FKBP-MCAK CRISPR cells we found that one deleterious hotspot mutation increased chromosome instability in a wild-type background suggesting that such mutants have the potential to promote tumor karyotype evolution.
The expression of MCAK was significantly associated with aggressive features of breast cancer, including tumor stage, Elston grade, and molecular subtypes, for global gene expression datasets of breast cancer (p<0.05).
NY-CO-58/KIF2C is significantly overexpressed in colorectal and other epithelial cancers and expression levels correlate with the proliferative activity of the tumor.