|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In wildtype mice and mice deficient in VWF and ADAMTS13, we investigated the outcome of S. aureus sepsis and quantified bacterial clearance and organ microthrombi.
|
31758651 |
2020 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
On the first day of admission, MEDS score, ADAMTS-13, and vWF/AMAMTS-13 ratio were independent predictors for 28-day mortality from sepsis.
|
31086585 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elevated citrullination of ADAMTS13 was observed in plasma samples of patients with sepsis or noninfected patients who were elderly (eg, age >65 years) and had underlying comorbidities (eg, diabetes mellitus and hypertension) as compared with healthy donors.
|
31248335 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case highlights that a C. canimorsus sepsis may cause a secondary TMA with a severe ADAMTS13 deficiency.
|
30222856 |
2018 |
|
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Protein C (> or ≤17%) and ADAMTS-13 percentage difference (> or ≤22%) were independently associated with sepsis outcome among the endothelial variables tested.
|
30159948 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, we discuss the possible benefit of restoring ADAMTS-13 levels or reducing the effect of ultralarge VWF as an adjunctive treatment in patients with sepsis.
|
29337416 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with mild or no deficiency, moderate ADAMTS13 deficiency correlated with older age; higher bilirubin and international normalized ratio; and increased frequency of sepsis, shock, or multiorgan failure.
|
28635017 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, VWF and ADAMTS13 have been recently proposed as prognostic biomarkers in cardiovascular, metabolic, and inflammatory diseases, such as diabetes, stroke, myocardial infarction, and sepsis.
|
28634421 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, the current status of mediators of endothelial cell function (angiopoietins-1 and -2), components of the coagulation pathway (von Willebrand Factor, ADAMTS13, and thrombomodulin), soluble cell-surface adhesion molecules (soluble E-selectin, sICAM-1, and sVCAM-1), and regulators of vascular tone and permeability (VEGF and sFlt-1) as biomarkers in severe infectious diseases is discussed in the context of sepsis, E. coli O157:H7 infection, malaria, and dengue virus infection.
|
23669075 |
2013 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that in vitro oxidation of Met1606 hinders vWF cleavage by ADAMTS-13, resulting in the accumulation of UL-vWF that are not only more pro-thrombotic than shorter vWF oligomers, but also more efficient in binding to bacterial adhesins during sepsis.
|
22091998 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the role of ADAMTS13 and VWF in the severity and outcome of sepsis.
|
20390223 |
2010 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition to TTP, ADAMTS13 levels were severely decreased in patients with sepsis-induced disseminated intravascular coagulation (DIC).
|
16189276 |
2006 |