CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Disease: Amyotrophic Lateral Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 Biomarker disease BEFREE CHIT1 and YKL-40 were increased in gALS (p<0.001, n=65) whereas GFAP was not affected. 30224549 2019
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 Biomarker disease BEFREE In CSF, CHIT1, YKL-40 and MCP-1 showed a weak discriminatory performance between ALS and ALS mimics (area under the curve: 0.79, p<0.0001; 0.72, p=0.001; 0.75, p=0.001, respectively). 31175169 2019
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 GeneticVariation disease BEFREE Chitinase proteins distinguished ALS from healthy controls (area under the curve (AUC): CHIT1 0.92; CHI3L1 0.80; CHI3L2 0.90), mimics (AUC: CHIT1 0.84; CHI3L1 0.73; CHI3L2 0.88) and, to a lesser extent, PLS (AUC: CHIT 0.73; CHI3L1 0.51; CHI3L2 0.82) but did not outperform pNFH. 31123140 2019
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 Biomarker disease BEFREE YKL-40 is potentially associated with the rate of ALS progression. 31195846 2019
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 Biomarker disease BEFREE Elevated CHI3L1 was common to ALS and PLS, whereas CHIT1 and CHI3L2 levels differed. 29331073 2018
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 AlteredExpression disease BEFREE We found increased levels of YKL-40 and decreased levels of sAPPβ in both FTD and ALS groups compared to controls. 30291183 2018
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.070 AlteredExpression disease BEFREE We showed that CHI3L1 and CHI3L2 were significantly upregulated in sALS smokers compared to non-smokers. 28989002 2017