CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Disease: Rectal Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.040 Biomarker disease BEFREE These results provide a rationale for the potential use of anti-YKL-40 and anti-angiogenic strategies in treating rectal cancer. 29731892 2018
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.040 Biomarker disease BEFREE Finally, in patients with recurrence, the percentage of cases with increased concentration of YKL-40 was significantly higher than in patients without recurrence ( P = .041), and Kaplan-Meier analysis demonstrated that elevated YKL-40 concentration is a predictor of poor overall survival in patients with rectal cancer. 29642772 2018
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.040 GeneticVariation disease BEFREE A significant association of SNP in SMAD7 rs4939827 and CHI3L1 rs4950928 was revealed between the rectal cancer and colon cancer patients. 26779637 2016
CUI: C0007113
Disease: Rectal Carcinoma
Rectal Carcinoma 		0.040 Biomarker disease BEFREE Here, c-Met and YKL-40 have been studied as putative predictors of CRT response in rectal cancer, due to their reported involvement in chemoradioresistance in various solid tumors. 25875173 2015