CHI3L1, chitinase 3 like 1, 1116

N. diseases: 420; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 Biomarker disease BEFREE We examined serum samples from 93 NAFLD patients and 19 healthy donors (HDs) for macrophage-associated protein, including sSiglec-7, soluble CD163, and YKL-40, and examined their correlation with liver fibrosis scores, tissue elastography, and histological findings. 31808236 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 Biomarker disease BEFREE Serum markers such as chitinase-3-like protein 1 (CHI3L1) also known as YKL-40, aspartate aminotransferase-to-platelet ratio index, and fibrosis-4 (Fib-4) index have been researched as potential alternates to detect liver fibrosis. 30431458 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 Biomarker disease BEFREE Chitinase 3-like 1 exacerbates liver fibrosis progression by suppressing apoptosis in hepatic macrophages. 31250532 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 AlteredExpression disease BEFREE Changes in serum chitinase 3-like 1 levels correlate with changes in liver fibrosis measured by two established quantitative methods in chronic hepatitis B patients following antiviral therapy. 28895260 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 Biomarker disease BEFREE This study aimed to determine whether YKL-40 could serve as a diagnostic marker for the assessment of liver fibrosis in chronic hepatitis B patients with normal and mildly elevated ALT. 29600444 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 Biomarker disease BEFREE Finally, we showed that CHI3L1 is superior to hyaluronic acid (HA), type III procollagen (PCIII), laminin (LN), and type IV collagen (CIV), which are also serum biomarkers of liver fibrosis, in identifying advanced liver fibrosis in patients with HBV-related liver fibrosis in China. 26415140 2015
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver
0.070 GeneticVariation disease BEFREE The CHI3L1 promoter polymorphism -131G-->C determines YKL-40 serum levels and is associated with the severity of HCV-induced liver fibrosis. 19070929 2009