|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Four phosSNPs in ADAMTS7 were significantly associated with CAD, including the known functional SNP rs3825807.
|
31456518 |
2019 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the data showed that common variants in ADAMTS7 and ZC3HC1 genes contribute to an increased risk for both CAD and LA (atherosclerotic) IS.
|
31679296 |
2019 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs at the known CAD risk loci ADAMTS7 (rs11634042) and VAMP8 (rs1561198) passed the pre-assigned selection criteria (P<sub>AgP-Ger</sub> < 0.05; P<sub>CAD</sub> < 5 × 10<sup>-8</sup>; concordant effect direction) and were replicated in an independent GWAS meta-analysis dataset of PD (4,415 cases vs 5,935 controls).
|
30209331 |
2018 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
ADAMTS7 is strongly associated with coronary artery disease and promotes atherosclerosis.
|
29885460 |
2018 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
SNP rs12286 was significantly associated with CAD at genome-wide level (p = 4.5 × 10<sup>-9</sup>). rs12286 was predicted to influence m<sup>6</sup>A methylation and have the potential to alter regulatory motifs binding, which may in turn regulate the expression of ADAMTS7 (p = 1.26 × 10<sup>-8</sup>).
|
30221544 |
2018 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The lead CAD-associated single-nucleotide polymorphism rs3825807 at the ADAMTS7 locus was genotyped.
|
29089340 |
2017 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found that ADAMTS7 rs3825807 was associated with susceptibility to CAD in a Chinese population [odds ratio (OR) = 1.15, 95 % confidence interval (CI) = 1.05-1.26, P = 0.002].
|
26189211 |
2016 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We also took advantage of the fact that penalized methods are an efficient approach to search for gene-by-gene interactions, and observed that two-way interactions between the PHACTR1 and ADAMTS7 loci and between the SH2B3 and COL4A1 loci contribute to CAD risk.
|
26982883 |
2016 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we tested whether ADAMTS7 (A/G) SNP is associated with cardiovascular (CV) survival in patients with established CAD.
|
27614204 |
2016 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the mechanisms that link ADAMTS-7 and coronary artery disease risk remain elusive.
|
25712208 |
2015 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, these studies fail to provide directionality for the association between ADAMTS7 and coronary artery disease.
|
25712206 |
2015 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
For ADAMs with ThromboSpondin domains (ADAMTSs), there are biological and genome-wide association data linking ADAMTS-7 to incidence of coronary heart disease but not increased risk of myocardial infarctions.
|
25089553 |
2014 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This editorial highlights these findings and discusses targeted ADAMTS7 inhibition as a possible novel approach to treat CAD.
|
23829786 |
2013 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Coronary Artery Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of our study indicate that rs3825807 has an effect on ADAMTS7 maturation, thrombospondin-5 cleavage, and VSMC migration, with the variant associated with protection from atherosclerosis and CAD rendering a reduction in ADAMTS7 function.
|
23415669 |
2013 |
|
Coronary Artery Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
|
21378990 |
2011 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
ADAMTS7 and ZC3HC1 Share Genetic Predisposition to Coronary Artery Disease and Large Artery Ischemic Stroke.
|
31679296 |
2019 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
ADAMTS7 is strongly associated with coronary artery disease and promotes atherosclerosis.
|
29885460 |
2018 |
|
Coronary Arteriosclerosis
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Serum ADAMTS7 levels in patients with unstable angina pectoris were much higher than in non-atherosclerotic patients, however, no difference was found among non-atherosclerotic patients, the coronary atherosclerosis subgroup and stable angina pectoris subgroup.
|
29980058 |
2018 |
|
Coronary Arteriosclerosis
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Association of ADAMTS7 gene polymorphism with cardiovascular survival in coronary artery disease.
|
27614204 |
2016 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
However, these studies fail to provide directionality for the association between ADAMTS7 and coronary artery disease.
|
25712206 |
2015 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
However, the mechanisms that link ADAMTS-7 and coronary artery disease risk remain elusive.
|
25712208 |
2015 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
For ADAMs with ThromboSpondin domains (ADAMTSs), there are biological and genome-wide association data linking ADAMTS-7 to incidence of coronary heart disease but not increased risk of myocardial infarctions.
|
25089553 |
2014 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
ADAMTS7: a promising new therapeutic target in coronary heart disease.
|
23829786 |
2013 |
|
Coronary Arteriosclerosis
|
0.390 |
Biomarker
|
disease |
BEFREE |
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
|
21239051 |
2011 |