Tuberculosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
These results demonstrate a strong association of SNPs in the PKP3-SIGIRR-TMEM16J gene region and tuberculosis in discovery and validation cohorts.
|
22223854 |
2012 |
Tuberculosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Low Vitamin-D Levels Combined with PKP3-SIGIRR-TMEM16J Host Variants Is Associated with Tuberculosis and Death in HIV-Infected and -Exposed Infants.
|
26872154 |
2016 |
Carcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The differential expression of the PKP3 variants has been observed in a similar manner in selected normal human tissues and carcinomas derived thereof.
|
24178805 |
2014 |
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
PKP3 loss leads to an increase in invasion, tumour formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression.
|
29803740 |
2018 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The results suggest that MMP7 over-expression may be one of the mechanisms by which PKP3 loss leads to increased cell invasion and tumor formation.
|
25875355 |
2015 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
According to our study, plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma.
|
29722422 |
2018 |
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
We conclude that high Pkp2, and low Pkp3, expression is associated with bladder cancer cell invasion and that neither Pkp2 nor Pkp3 is associated with cell proliferation.
|
22119253 |
2012 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
PKP3 loss leads to an increase in invasion, tumour formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression.
|
29803740 |
2018 |
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that a stabilisation of K8 filaments leading to an increase in migration and transformation may be one mechanism by which PKP3 loss leads to tumor progression and metastasis.
|
22701666 |
2012 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Plakophilin3 (PKP3) loss results in increased transformation in multiple cell lines in vitro and increased tumor formation in vivo.
|
25875355 |
2015 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
To identify pathways downstream of PKP3 loss that are required for increased tumour formation, a gene expression analysis was performed, which demonstrated that the expression of lipocalin2 (LCN2) was elevated upon PKP3 loss and this is consistent with expression data from human tumour samples suggesting that PKP3 loss correlates with an increase in LCN2 expression.
|
29803740 |
2018 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that a stabilisation of K8 filaments leading to an increase in migration and transformation may be one mechanism by which PKP3 loss leads to tumor progression and metastasis.
|
22701666 |
2012 |
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression.
|
17391671 |
2007 |
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Further, the K8 PKP3 double knockdown clones showed a decrease in colony formation in soft agar and decreased tumorigenesis and metastasis in nude mice.
|
22701666 |
2012 |
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Plakophilin 3 is a protein present in desmosomes of stratified and simple epithelia of normal tissues with presence in malignant cells of various tumors where it participates in the process of tumorigenesis.
|
29722422 |
2018 |
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In one example, we have shown that Pkp3 is instrumental in mediating the discohesive effects of sera from patients with pemphigus vulgaris (PV), a life-threatening autoimmune disease that targets intercellular adhesion in the epidermis.
|
24328683 |
2014 |
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 has demonstrated a role in melanoma, breast cancer, gastric cancer, and other kind of cancers; however its role in ovarian cancer was not fully understood.
|
30527804 |
2019 |
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
As our data imply that up-regulation of PKP3 is a frequent and important feature of lung carcinogenesis, we suggest that targeting the PKP3 molecule might hold promise for development of a new therapeutic and diagnostic strategy for clinical management of lung cancers.
|
16103059 |
2005 |
Malignant mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
According to our study, plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma.
|
29722422 |
2018 |
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.
|
16103059 |
2005 |
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 also modulate cellular proliferation and invasion in ovarian cancer.
|
30527804 |
2019 |
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 also modulate cellular proliferation and invasion in ovarian cancer.
|
30527804 |
2019 |
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.
|
16103059 |
2005 |