|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.
|
16103059 |
2005 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Plakophilin 3 oncogene as prognostic marker and therapeutic target for lung cancer.
|
16103059 |
2005 |
|
Tumor Progression
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
PKP3 mRNA in blood was associated with the risk of cancer progression and death.
|
20501752 |
2010 |
|
Malignant neoplasm of gastrointestinal tract
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PKP3 mRNA can be used as a marker of subclinical disease in gastrointestinal cancer and thus holds potential clinical relevance as a predictor for disease outcome.
|
20501752 |
2010 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Plakophilin 3 is a protein present in desmosomes of stratified and simple epithelia of normal tissues with presence in malignant cells of various tumors where it participates in the process of tumorigenesis.
|
29722422 |
2018 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
PKP3 loss leads to an increase in invasion, tumour formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression.
|
29803740 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
PKP3 loss leads to an increase in invasion, tumour formation and metastasis and these phenotypes were dependent on the increase in LCN2 expression.
|
29803740 |
2018 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 has demonstrated a role in melanoma, breast cancer, gastric cancer, and other kind of cancers; however its role in ovarian cancer was not fully understood.
|
30527804 |
2019 |
|
ovarian neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 also modulate cellular proliferation and invasion in ovarian cancer.
|
30527804 |
2019 |
|
Malignant neoplasm of ovary
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 also modulate cellular proliferation and invasion in ovarian cancer.
|
30527804 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
PKP3 also modulate cellular proliferation and invasion in ovarian cancer.
|
30527804 |
2019 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
A higher blood level of PKP3 mRNA was associated with a more advanced stage (P = 0.025), pT(3-4) tumors (P = 0.028), metastasis (P = 0.021), and residual (R2) disease (P = 0.037).
|
20501752 |
2010 |
|
ROSE Cluster 2
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A higher blood level of PKP3 mRNA was associated with a more advanced stage (P = 0.025), pT(3-4) tumors (P = 0.028), metastasis (P = 0.021), and residual (R2) disease (P = 0.037).
|
20501752 |
2010 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
According to our study, plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma.
|
29722422 |
2018 |
|
Malignant mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
According to our study, plakophilin 3 appears to be involved in tumor invasion in malignant mesothelioma.
|
29722422 |
2018 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
As our data imply that up-regulation of PKP3 is a frequent and important feature of lung carcinogenesis, we suggest that targeting the PKP3 molecule might hold promise for development of a new therapeutic and diagnostic strategy for clinical management of lung cancers.
|
16103059 |
2005 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
As our data imply that up-regulation of PKP3 is a frequent and important feature of lung carcinogenesis, we suggest that targeting the PKP3 molecule might hold promise for development of a new therapeutic and diagnostic strategy for clinical management of lung cancers.
|
16103059 |
2005 |
|
Gastrointestinal Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer.
|
18801625 |
2008 |
|
Nasopharyngeal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dinitrosopiperazine-decreased PKP3 through upregulating miR-149 participates in nasopharyngeal carcinoma metastasis.
|
30144176 |
2018 |
|
Malignant Pleural Mesothelioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of plakophilin 3 in diffuse malignant pleural mesothelioma.
|
29722422 |
2018 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Further, the K8 PKP3 double knockdown clones showed a decrease in colony formation in soft agar and decreased tumorigenesis and metastasis in nude mice.
|
22701666 |
2012 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High PKP3 expression was associated with lymph node metastasis (LNM, P = .004) and advanced International Federation of Gynecology and Obstetrics (FIGO) stage (P = .013).
|
30855445 |
2019 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Malignant neoplasm of prostate
|
0.300 |
Biomarker
|
disease |
CTD_human |
Identification of genes potentially involved in the acquisition of androgen-independent and metastatic tumor growth in an autochthonous genetically engineered mouse prostate cancer model.
|
17013881 |
2007 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, a high level of PKP3 expression was associated with poor survival as well as disease stage and node status for patients with lung adenocarcinoma, suggesting an important role of the protein in development and progression of this disease.
|
16103059 |
2005 |