|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we evaluated the presence and frequency of 1100delC and Del5395 mutations in CHEK2 gene in Serbian BRCA-negative HBOC cases.
|
24065469 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Spectrum of mutations in BRCA1, BRCA2, CHEK2, and TP53 in families at high risk of breast cancer.
|
16551709 |
2006 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Constitutional CHEK2 mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan.
|
23806170 |
2013 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Improving performance of multigene panels for genomic analysis of cancer predisposition.
|
26845104 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
|
18571837 |
2008 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India.
|
14507240 |
2003 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Nowadays CHK2 mutation is studied frequently in hereditary breast and ovarian cancer patients in addition to BRCA1/BRCA2.
|
31398194 |
2019 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Complexities of Variant Classification in Clinical Hereditary Cancer Genetic Testing.
|
28981386 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Hereditary cancer screening: Case reports and review of literature on ten Ashkenazi Jewish founder mutations.
|
30152102 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
ORPHANET |
Two new CHEK2 germ-line variants detected in breast cancer/sarcoma families negative for BRCA1, BRCA2, and TP53 gene mutations.
|
21562711 |
2011 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.
|
26898890 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Mutation screening of TP53, CHEK2 and BRCA genes in patients at high risk for hereditary breast and ovarian cancer (HBOC) in Brazil.
|
30535581 |
2019 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Prevalence of deleterious mutations among patients with breast cancer referred for multigene panel testing in a Romanian population.
|
29785153 |
2018 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population.
|
15649950 |
2005 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Response to DNA damage of CHEK2 missense mutations in familial breast cancer.
|
22419737 |
2012 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.
|
27798748 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Conflicting Interpretation of Genetic Variants and Cancer Risk by Commercial Laboratories as Assessed by the Prospective Registry of Multiplex Testing.
|
27621404 |
2016 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Finally we have seen that the analyses of other HBOC risk gene TP53 and specific mutation in CHEK2*c.1100delC in Slovak HBOC families were not efficient since no mutations were found in these genes.
|
21203900 |
2011 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory.
|
24506336 |
2014 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Germline CHEK2 mutations in Jewish Ashkenazi women at high risk for breast cancer.
|
18085035 |
2007 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
|
25503501 |
2015 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Efforts Toward Consensus Variant Interpretation by Commercial Laboratories.
|
28135139 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Multigene panels in Ashkenazi Jewish patients yield high rates of actionable mutations in multiple non-BRCA cancer-associated genes.
|
28495237 |
2017 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
CHEK2-positive breast cancers in young Polish women.
|
16914568 |
2006 |
|
Hereditary Breast and Ovarian Cancer Syndrome
|
0.460 |
GeneticVariation
|
disease |
CLINVAR |
Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.
|
18706089 |
2008 |