CHEK2, checkpoint kinase 2, 11200

N. diseases: 297; N. variants: 261
Disease: Neuroectodermal Tumor, Primitive ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206663
Disease: Neuroectodermal Tumor, Primitive
Neuroectodermal Tumor, Primitive 		0.010 AlteredExpression disease BEFREE In conclusion, UCHL1 loss correlates with metastatic potential in PNETs and its re-expression induces a less aggressive phenotype in vitro, in part by inducing cell-cycle arrest through post-translational regulation of phosphorylated CHK2. 30689542 2019