AKAP10, A-kinase anchoring protein 10, 11216

N. diseases: 28; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0264886
Disease: Conduction disorder of the heart
Conduction disorder of the heart 		0.500 Biomarker group CTD_human
CUI: C0264886
Disease: Conduction disorder of the heart
Conduction disorder of the heart 		0.500 Biomarker group GENOMICS_ENGLAND
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation. 21382426 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 GeneticVariation disease BEFREE We found that SNPs in the AKAP10 and PRKCI genes are significantly associated with bipolar disorder and gene expression variation. 21382426 2011
CUI: C1867013
Disease: Increased risk of sudden cardiac death
Increased risk of sudden cardiac death 		0.300 Biomarker phenotype GENOMICS_ENGLAND
CUI: C1305855
Disease: Body mass index
Body mass index 		0.100 GeneticVariation phenotype GWASCAT Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 29273807 2018
CUI: C0032181
Disease: Platelet Count measurement
Platelet Count measurement 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C0200665
Disease: Platelet mean volume determination (procedure)
Platelet mean volume determination (procedure) 		0.100 GeneticVariation phenotype GWASCAT The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease. 27863252 2016
CUI: C4528257
Disease: Corpuscular Hemoglobin Concentration Mean
Corpuscular Hemoglobin Concentration Mean 		0.100 GeneticVariation phenotype GWASDB Seventy-five genetic loci influencing the human red blood cell. 23222517 2012
CUI: C0003811
Disease: Cardiac Arrhythmia
Cardiac Arrhythmia 		0.100 Biomarker phenotype HPO
CUI: C0011071
Disease: Sudden death
Sudden death 		0.100 Biomarker phenotype HPO
CUI: C0039070
Disease: Syncope
Syncope 		0.100 Biomarker phenotype HPO
CUI: C4016898
Disease: CARDIAC CONDUCTION DEFECT, SUSCEPTIBILITY TO
CARDIAC CONDUCTION DEFECT, SUSCEPTIBILITY TO 		0.100 SusceptibilityMutation phenotype CLINVAR
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression disease BEFREE Increased expression of AKAP10 in CRC patients was positively associated with the depth of invasion and the grade of differentiation. 25213315 2015
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression disease BEFREE We found that the positive expression rate of AKAP10 in colorectal cancer (59 %) was significantly higher than those in adenoma (39 %) and distant normal mucosa (42 %) (P = 0.004). 23468363 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 GeneticVariation disease BEFREE Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population. 19209010 2009
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 AlteredExpression phenotype BEFREE Increased expression of AKAP10 in CRC patients was positively associated with the depth of invasion and the grade of differentiation. 25213315 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 GeneticVariation group BEFREE The 1936G (V646) AKAP10 allele has been associated with adults with low cholinergic/vagus nerve sensitivity and with newborns with increased blood pressure. 23095189 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 GeneticVariation group BEFREE The 1936G AKAP10 allele is associated with increased adult basal heart rate (HR) and decreased variability, markers of low cholinergic/vagus sensitivity associated with hypertension. 22817328 2013
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Positive AKAP10 staining was correlated with deeper tumor invasion (P < 0.001), lymph nodes metastasis (P = 0.022), advanced tumor stage (P < 0.001) and poorly differentiated degree (P = 0.003). 23468363 2013
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 AlteredExpression disease BEFREE We found that the positive expression rate of AKAP10 in colorectal cancer (59 %) was significantly higher than those in adenoma (39 %) and distant normal mucosa (42 %) (P = 0.004). 23468363 2013
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 GeneticVariation disease BEFREE The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer. 19209010 2009
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 AlteredExpression disease BEFREE The AKAP10 expression at the mRNA and protein level have been analyzed in colon cancer cell lines, primary CRCs and matched normal mucosa samples, and compared in accordance with specific clinicopathological features of CRC. 25213315 2015
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 AlteredExpression disease BEFREE The AKAP10 expression at the mRNA and protein level have been analyzed in colon cancer cell lines, primary CRCs and matched normal mucosa samples, and compared in accordance with specific clinicopathological features of CRC. 25213315 2015
CUI: C0001430
Disease: Adenoma
Adenoma 		0.010 AlteredExpression group BEFREE We found that the positive expression rate of AKAP10 in colorectal cancer (59 %) was significantly higher than those in adenoma (39 %) and distant normal mucosa (42 %) (P = 0.004). 23468363 2013