|
Dermatitis, Atopic
|
0.030 |
Biomarker
|
disease |
LHGDN |
The results showed that virtually all CRTH2+CD4+ lymphocytes had a pure T helper 2 phenotype and formed not all but a large proportion of circulating T helper 2 cells for both normal and atopic dermatitis subjects.
|
12230502 |
2002 |
|
Eosinophilia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.
|
12975488 |
2003 |
|
Eosinophilic disorder
|
0.020 |
Biomarker
|
group |
BEFREE |
Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats.
|
12975488 |
2003 |
|
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Pharmacologically, rat CRTH2 stably transfected in mouse preB lymphoma L1.2 cells behaved very similar compared with the mouse and human orthologs, showing a binding affinity for PGD2 of 11 nM, a functional calcium mobilization when exposed to agonist, and similar sensitivity to agonists and antagonists.
|
12975488 |
2003 |
|
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pharmacologically, rat CRTH2 stably transfected in mouse preB lymphoma L1.2 cells behaved very similar compared with the mouse and human orthologs, showing a binding affinity for PGD2 of 11 nM, a functional calcium mobilization when exposed to agonist, and similar sensitivity to agonists and antagonists.
|
12975488 |
2003 |
|
Childhood Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Pharmacologically, rat CRTH2 stably transfected in mouse preB lymphoma L1.2 cells behaved very similar compared with the mouse and human orthologs, showing a binding affinity for PGD2 of 11 nM, a functional calcium mobilization when exposed to agonist, and similar sensitivity to agonists and antagonists.
|
12975488 |
2003 |
|
Adenoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we studied expression of DP1 and DP2 receptors by reverse transcription-polymerase chain reaction analysis of receptor mRNA levels in five human colorectal cancer cell lines (HT-29, HCA-7, HCT116, SW480 and SW48) and VACO-235 human colorectal adenoma cells.
|
15172124 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Family-based analysis of asthma and two common SNPs [G1544C and G1651A (rs545659)] in the 3'-untranslated region of CRTH2 showed significant evidence of linkage in the presence of disequilibrium for the 1651G allele (P = 0.003) of SNP rs545659.
|
15345705 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Family-based analysis of asthma and two common SNPs [G1544C and G1651A (rs545659)] in the 3'-untranslated region of CRTH2 showed significant evidence of linkage in the presence of disequilibrium for the 1651G allele (P = 0.003) of SNP rs545659.
|
15345705 |
2004 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, in the Chinese children the frequency of the chemoattractant receptor-homologous molecule expressed on T helper 2 cells (CRTH2) 1651G allele in near-fatal asthmatics was significantly higher than in mild-to-moderate asthmatics and normal controls.
|
15986064 |
2005 |
|
Bronchial Hyperreactivity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CRTH2 1651G allele of single nucleotide polymorphism re545659 was also associated with a higher degree of bronchial hyperresponsiveness.
|
15986064 |
2005 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data failed to support previous associations of functional polymorphisms at the 3'-UTR of the CRTH2 gene implicated in asthma.
|
17016057 |
2007 |
|
Inflammation
|
0.010 |
Biomarker
|
phenotype |
LHGDN |
The PGD(2)/CRTH2 system mediates the chemotaxis of eosinophils, basophils, and Th2 cells, which are involved in the induction of allergic inflammation.
|
17541272 |
2007 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.
|
18757520 |
2008 |
|
Dermatitis, Atopic
|
0.030 |
Biomarker
|
disease |
BEFREE |
Prostaglandin D(2), the ligand for the G protein-coupled receptors DP1 and CRTH2, has been implicated in the pathogenesis of the allergic response in diseases such as asthma, rhinitis, and atopic dermatitis.
|
18757520 |
2008 |
|
Eczema
|
0.020 |
Biomarker
|
disease |
BEFREE |
Prostaglandin D(2), the ligand for the G protein-coupled receptors DP1 and CRTH2, has been implicated in the pathogenesis of the allergic response in diseases such as asthma, rhinitis, and atopic dermatitis.
|
18757520 |
2008 |
|
Pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
We investigated the role of PGD(2) and CRTH2 in allergic pulmonary inflammation by using a highly potent and specific antagonist of CRTH2.
|
18757520 |
2008 |
|
Pneumonitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
We investigated the role of PGD(2) and CRTH2 in allergic pulmonary inflammation by using a highly potent and specific antagonist of CRTH2.
|
18757520 |
2008 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic variations in chemoattractant receptor expressed on Th2 cells (CRTH2) is associated with asthma susceptibility in Chinese children.
|
18777142 |
2009 |
|
Nasal Polyps
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Significantly greater levels of DP mRNA and conversely decreased levels of CRTH2 mRNA were observed in NP compared with UPM.
|
18802357 |
2009 |
|
Chronic sinusitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Expression and characterization of PGD2 receptors in chronic rhinosinusitis: modulation of DP and CRTH2 by PGD2.
|
18802357 |
2009 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We sought to determine the expression and characterization of DP and CRTH2 in CRS.
|
18802357 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, genetic association studies have shown a positive linkage of the genetic polymorphisms in DP and CRTH2, with asthma phenotypes from specific ethnic backgrounds, further highlighting the importance of PGD(2) and its receptors in the pathophysiology of asthma.
|
18946232 |
2008 |
|
Chronic urticaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The CRTH2 -466T>C gene polymorphism may not affect on the phenotype of CU, but contributes to the required dose of antihistamines in patients with CU.
|
19290788 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children.
|
19392992 |
2009 |